Decreased level of ceramides in stratum corneum of atopic dermatitis : an etiologic factor in atopic dry skin ?

Mode of action of penetration enhancers in human skin

Publisher Summary This chapter discusses the structural and lipid biochemical correlates of the epidermal permeability barrier. A pivotal point in terrestrial adaptation is prevention of desiccation and maintenance of internal water homeostasis. The outermost integumentary tissue, the epidermis, maintains a reserve of germinal cell layers whose proliferation, stratification, and differentiation result in the production of the outermost layer, the anucleate stratum corneum. The stratum corneum has heterogeneous tissue structure possessing a selected array of enzymatic activity. The sequestration of lipids to intercellular domains and their organization into a unique multilamellar system have broad implications for permeability barrier function, water retention, desquamation, and percutaneous drug delivery. Yet, the functions and organization of specific lipid species in this membrane system are still unknown. Further, elucidation of the molecular architecture and interactions of lipid and nonlipid components of the stratum corneum intercellular domains will be a prerequisite for a comprehensive understanding of stratum corneum function.

Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier

Pathways of O-glycan biosynthesis in cancer cells.

Stratum Corneum Moisturization at the Molecular Level

Selective recovery of deranged water-holding properties by stratum corneum lipids

A possible function of structural lipids in the water-holding properties of the stratum corneum.

Purification, cDNA Cloning, and Expression of UDP-Gal: Glucosylceramide beta-1,4-galactosyltransferase From Rat Brain

ジアシルグリセリン (DG) は, 血清トリアシルグリセリン (TG) の上昇を抑制する脂質である。1, 3-DGと1, 2-DGから成るDGの栄養学的特徴を, ラットで検討した。DGとTGの間には, 消化及び代謝過程において, 明らかな違いが認められた。結果は次の通りである。 (1) 小腸内において, DGからはTGの消化物中にはほとんど見られなかった1-モノアシルグリセリンが生成した。 (2) DG投与後には, TGと比較して多量の脂肪酸が小腸から門脈へ放出された。 (3) DG摂取は, 肝臓での脂肪酸のβ酸化を促進し, ケトン体を尿中へ放出させた。 (4) ラットにおいて, DG投与後の酸素消費量は, TG投与後に比べて増加した。これらの結果から, DGはエネルギーとして利用されやすく, そのためTGと比較して体脂肪として蓄積しにくいものと考えられた。

Nutritional Characterization of Diacylglycerols in Rats

An external medicament comprises a novel amide derivative represented by the following formula (I). ##STR1## The external medicament is applicable to both a pharmaceutical external medicament and a cosmetic composition, and it provides excellent improving and preventing effects for chapping of the skin.

Michihiro Hattori

Papers

Selective recovery of deranged water-holding properties by stratum corneum lipids

A possible function of structural lipids in the water-holding properties of the stratum corneum.

Purification, cDNA Cloning, and Expression of UDP-Gal: Glucosylceramide beta-1,4-galactosyltransferase From Rat Brain

Nutritional Characterization of Diacylglycerols in Rats

Amide derivative and external medicament comprising same