Michiko Watari

TL;DR: Rec recombinant EDA, but not other recombinant fibronectin domains, activates human TLR4 expressed in a cell type (HEK 293 cells) that normally lacks this Toll-like receptor.

TL;DR: Niemann-Pick type C (NPC) disease is concluded that NPC1 is a glycoprotein that must have an intact sterol-sensing domain and leucine zipper motif for cholesterol-mobilizing activity.

TL;DR: The ability of PGE(2) to induce expression of the HA-binding protein, tumor necrosis factor-stimulated gene (TSG)-6, in human cervical smooth muscle cells (hCSMCs) is examined and the PGE (2) response to that of tumor necrotic factor-alpha (TNF-alpha), an established inducer of TSG-6 are compared.

TL;DR: Vaginal and amniotic infection with gram-negative bacteria is associated with preterm birth and the previously reported that human cervical smooth-muscle cells (CSMC) respond to pro-inflammatism.

TL;DR: It is concluded that cis elements residing in the first 111 base pairs upstream from the transcription start site are critical for transcription of the NPC1 gene; that NPC1 expression is subject to posttranscriptional regulation in response to treatments that disrupt NPC1 function; and that an intralumenal cysteine-rich loop with zinc-binding activity is critical to NPC1's ability to unload lysosomal cargo.