Michiyo Saimura

TL;DR: This in vitro study sketched out the interaction between cancerous and stromal compartments with an emphasis on HGF/c-Met signal pathway, thus possibly helping to unveil the more complicated mutual modulation in vivo between pancreatic cancer and host mesenchymal tissues.

TL;DR: It is indicated that the intraperitoneal transduction of adenovirus-mediated NK4 gene may be a useful therapeutic modality to prevent the development of peritoneal dissemination of pancreatic cancer.

TL;DR: The results of these experiments show that genetic modification of tumor cells with NK4 cDNA yields a significant antitumor effect and that this effect is mainly obtained by NK4's function as an angiogenesis inhibitor rather than as an HGF antagonist.

TL;DR: Peritumoral injection of Ad-NK4 plus GEM is a potent combination therapy for pancreatic cancer, and Histologic and immunohistochemical assays of primary tumors indicated that combination therapy prohibited both cell proliferation and angiogenesis, resulting in high levels of apoptosis.

TL;DR: Results indicate that intraportal injection of Ad‐NK4 may be a useful therapeutic modality for the clinical control of hepatic metastasis in pancreatic cancer.