M
Miguel Ángel Fernández-Moreno
Researcher at Spanish National Research Council
Publications - 50
Citations - 2266
Miguel Ángel Fernández-Moreno is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrion. The author has an hindex of 23, co-authored 48 publications receiving 2027 citations. Previous affiliations of Miguel Ángel Fernández-Moreno include Carlos III Health Institute & Autonomous University of Madrid.
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Journal ArticleDOI
The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.
TL;DR: It is concluded that initiation of actinorhodin synthesis via the actII-ORF4 product, and the final step in production, antibiotic export, are twin targets via which bldA exerts developmental control of actarhodin production.
Journal ArticleDOI
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
Miguel Ángel Fernández-Moreno,Eduardo Sebastian Martinez,L Boto,David A. Hopwood,Francisco Malpartida +4 more
TL;DR: The data show that the actinorhodin PKS consists of discrete monofunctional components, like that of the Escherichia coli (Type II) FAS, rather than the multifunctional polypeptides for the macrolide PKSs and vertebrate FASs (Type I).
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Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2).
Leonid Bystrykh,Miguel Ángel Fernández-Moreno,J. K. Herrema,Francisco Malpartida,David A. Hopwood,Lubbert Dijkhuizen +5 more
TL;DR: The gamma-actinorhodin (the lactone) form of actinors was identified in the act mutants of S. coelicolor A3(2) as mentioned in this paper.
Journal ArticleDOI
Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein.
TL;DR: Although both gene products (wild-type and mutant ActII-ORF4) showed DNA-binding activity, only the wild-type gene was capable of activating transcription of the act genes; thus, two basic functions can be differentiated within the regulatory protein.
Journal ArticleDOI
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).
Miguel Ángel Fernández-Moreno,Eduardo Sebastian Martinez,José Luis Caballero,Koji Ichinose,David A. Hopwood,Francisco Malpartida +5 more
TL;DR: Findings strongly suggest that the actVI region is involved in catalyzing reduction processes that determine the two stereochemical configurations at C-3/C-15 during actinorhodin biosynthesis.