M
Miguel R. Branco
Researcher at Queen Mary University of London
Publications - 63
Citations - 7703
Miguel R. Branco is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 28, co-authored 57 publications receiving 6713 citations. Previous affiliations of Miguel R. Branco include Life Sciences Institute & Babraham Institute.
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Journal ArticleDOI
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
Gabriella Ficz,Miguel R. Branco,Stefanie Seisenberger,Fátima Santos,Felix Krueger,Timothy A. Hore,C. Joana Marques,C. Joana Marques,Simon Andrews,Wolf Reik,Wolf Reik +10 more
TL;DR: The balance between hydroxymethylation and methylation in the genome is inextricably linked with the balance between pluripotency and lineage commitment.
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Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution
Michael J. Booth,Miguel R. Branco,Miguel R. Branco,Gabriella Ficz,David Oxley,Felix Krueger,Wolf Reik,Wolf Reik,Shankar Balasubramanian +8 more
TL;DR: In this article, the first method for quantitative mapping of 5hmC in genomic DNA at single-nucleotide resolution was proposed. But the method was not applied to the case of mouse embryonic stem cells.
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Uncovering the role of 5-hydroxymethylcytosine in the epigenome
TL;DR: Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcyTosine in mammalian DNA, which led to the rapid accumulation of publications from a wide array of fields.
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Intermingling of Chromosome Territories in Interphase Suggests Role in Translocations and Transcription-Dependent Associations
Miguel R. Branco,Ana Pombo +1 more
TL;DR: It is suggested that local chromatin conformation and gene transcription influence the extent with which chromosomes interact and affect their overall properties, with direct consequences for cell-type specific genome stability.
Journal ArticleDOI
Complex multi-enhancer contacts captured by genome architecture mapping
Robert A. Beagrie,Antonio Scialdone,Markus Schueler,Dorothee C. A. Kraemer,Mita Chotalia,Sheila Q. Xie,Mariano Barbieri,Ines de Santiago,Liron-Mark Lavitas,Miguel R. Branco,James Fraser,Josée Dostie,Laurence Game,Niall Dillon,Paul A.W. Edwards,Mario Nicodemi,Ana Pombo +16 more
TL;DR: A genome-wide method for measuring chromatin contacts and other features of three-dimensional chromatin topology on the basis of sequencing DNA from a large collection of thin nuclear sections is reported, highlighting a role for gene-expression-specific contacts in organizing the genome in mammalian nuclei.