M
Mika Aoki
Researcher at Kao Corporation
Publications - 6
Citations - 54
Mika Aoki is an academic researcher from Kao Corporation. The author has contributed to research in topics: Chemistry & Papillary dermis. The author has an hindex of 3, co-authored 4 publications receiving 34 citations.
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Journal ArticleDOI
Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin.
Hiroyuki Yoshida,Aya Nagaoka,Aya Komiya,Mika Aoki,S. Nakamura,T. Morikawa,R. Ohtsuki,Tetsuya Sayo,Yasunori Okada,Yoshito Takahashi +9 more
TL;DR: It is shown that photoageing‐dependent changes in HA and their molecular mechanisms, and the relationship between HA metabolism and clinical symptoms in photoaged skin remain elusive.
Journal ArticleDOI
Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling.
Hiroyuki Yoshida,Kohei Yamazaki,Aya Komiya,Mika Aoki,Shinya Kasamatsu,T. Murata,Tetsuya Sayo,Mehmet Zeynel Cilek,Yasunori Okada,Yoshito Takahashi +9 more
TL;DR: Reduction in HA in the papillary dermis and over‐expression of HYBID, a key molecule for HA degradation in skin fibroblasts, are implicated in facial skin wrinkling in Japanese and Caucasian women.
Journal ArticleDOI
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts.
Hiroyuki Yoshida,Mika Aoki,Aya Komiya,Yoko Endo,Keigo Kawabata,Tomomi Nakamura,Shingo Sakai,Tetsuya Sayo,Yasunori Okada,Yoshito Takahashi +9 more
TL;DR: It is shown that histamine increases HA degradation by up-regulating HYBID and down- Regulating HAS2 in human skin fibroblasts in a dose- and time-dependent manner and thereby decreases the total amounts and sizes of newly produced HA.
Journal ArticleDOI
Inhibition of HYBID (KIAA1199)-mediated hyaluronan degradation and anti-wrinkle effect of Geranium thunbergii extract.
Hiroyuki Yoshida,Kohei Yamazaki,Aya Komiya,Mika Aoki,Tomomi Nakamura,Shinya Kasamatsu,Takeshi Murata,Tetsuya Sayo,Yasunori Okada,Yoshito Takahashi +9 more
TL;DR: HA reduction in the dermis and overexpression of HYBID (KIAA1199), a key molecule for HA degradation in skin fibroblasts, are implicated in facial skin wrinkling.
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Carbon dioxide-induced decrease in extracellular pH enhances the production of extracellular matrix components by upregulating TGF-β1 expression via CREB activation in human dermal fibroblasts.
TL;DR: In this paper , the effect and mechanism of mild acidity on extracellular matrix (ECM) protein production in normal human dermal fibroblasts (NHDFs) were examined by treating reconstructed human skin equivalents (HSEs) with a CO2-containing formulation.