Mikael Oscarson

TL;DR: For example, this article showed that 40% of human P450-dependent drug metabolism is carried out by polymorphic enzymes, which can cause abolished, quantitatively or qualitatively altered or enhanced drug metabolism.

TL;DR: Important interethnic differences exist in the structure of the CYP2D locus, and they suggest that the frequent distribution of the C188-->T mutation among the CYp2D6Ch genes explains the lower capacity among Chinese to metabolize drugs that are substrates of CYP 2D6, such as antidepressants and neuroleptic agents.

TL;DR: It is concluded that genotyping for the CYP2A6del allele is of great importance in studies correlating, for example, smoking behaviour, pre‐carcinogen activation or drug metabolism to the CYp2A 6 genotype, in particular when oriental populations are investigated.

TL;DR: In conclusion, the Saudi Arabian population studied exhibited very few defective alleles and a large number of subjects carried duplicated CYP2D6 genes, implying a high conservation on functional CYP1D7 genes possibly due to dietary reasons and reveal the Saudi Arabians as an unique population in comparison with others examined.

TL;DR: Re‐evaluated the genotyping method used for the CYP2A6*3 allele and found that a gene conversion in the 3′ flanking region of 30–40% of CYP6*1 alleles results in genotype misclassification, implying the presence of numerous defective as well as active CYP1A6/CYP2A7 gene conversion events.