M
Matti A. Lang
Researcher at University of Queensland
Publications - 134
Citations - 4334
Matti A. Lang is an academic researcher from University of Queensland. The author has contributed to research in topics: Cytochrome P450 & Microsome. The author has an hindex of 38, co-authored 133 publications receiving 4188 citations. Previous affiliations of Matti A. Lang include International Agency for Research on Cancer & Uppsala University.
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Journal ArticleDOI
Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population.
Mikael Oscarson,Roman A. McLellan,Harriet Gullstén,Qun-Ying Yue,Matti A. Lang,Maria Luisa Bernal,Blanca Sinués,Ari Hirvonen,Hannu Raunio,Olavi Pelkonen,Magnus Ingelman-Sundberg +10 more
TL;DR: It is concluded that genotyping for the CYP2A6del allele is of great importance in studies correlating, for example, smoking behaviour, pre‐carcinogen activation or drug metabolism to the CYp2A 6 genotype, in particular when oriental populations are investigated.
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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.
TL;DR: Western blot analysis of a panel of human livers indicates that the level of the 49 kDa protein, detected using antisera to either the mouse COH P-450 or rat P450IIA1 protein, correlates very highly with COH activity, which indicates that a member of the P 450IIA subfamily is responsible for most, if not all, of theCOH activity in human liver.
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High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans
A.-M. Camus,Olivier Geneste,Paavo Honkakoski,Jean-Claude Béréziat,Colin J. Henderson,Roland Wolf,Helmut Bartsch,Matti A. Lang +7 more
TL;DR: The data suggest that the metabolic activation of nitrosamines in humans varies greatly among individuals; (2) different nitrosamine may partially be metabolized by different cytochrome P450 isozymes; and (3) inbred strains of mice would be relevant experimental models for studyingNitrosamine activation.
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Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse.
Hannu Raunio,Tuula Syngelmä,Markku Pasanen,Risto O. Juvonen,Paavo Honkakoski,Matti Kairaluoma,Eero A. Sotaniemi,Matti A. Lang,Olavi Pelkonen +8 more
TL;DR: The data suggest that despite slightly differing molecular masses, the human and mouse P-450s supporting COH are structurally conserved at their active centers.
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Water quality assessment using the AREc32 reporter gene assay indicative of the oxidative stress response pathway
Beate I. Escher,Mriga Dutt,Erin Maylin,Janet Y. M. Tang,Simon Toze,C. Roland Wolf,Matti A. Lang +6 more
TL;DR: The reporter gene assay AREc32, based on the induction of the Nrf2 mediated oxidative stress response pathway in the human breast cancer cell line MCF7, is adopted and validated for water quality testing.