M
Mike Doran
Researcher at Thomas Jefferson University
Publications - 1
Citations - 98
Mike Doran is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Vascular endothelial growth factor A & Kinase insert domain receptor. The author has an hindex of 1, co-authored 1 publications receiving 89 citations.
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Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Atul Goyal,Nutan Pal,Matthew Concannon,Matthew Paul,Mike Doran,Chiara Poluzzi,Kiyotoshi Sekiguchi,John M. Whitelock,Thomas Neill,Renato V. Iozzo +9 more
TL;DR: It is demonstrated that both perlecan and endorepellin bind directly and with high affinity to both VEGF receptors 1 and 2, in a region that differs from VEGFA-binding site, and hypothesized that a mechanism such as dual receptor antagonism could operate for other angiostatic fragments.