M
Mike Ludwig
Researcher at University of Edinburgh
Publications - 114
Citations - 6555
Mike Ludwig is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Vasopressin & Supraoptic nucleus. The author has an hindex of 38, co-authored 111 publications receiving 6020 citations. Previous affiliations of Mike Ludwig include Leipzig University & Max Planck Society.
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Journal ArticleDOI
Dendritic peptide release and peptide-dependent behaviours
Mike Ludwig,Gareth Leng +1 more
TL;DR: The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.
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Intranasal Oxytocin: Myths and Delusions
Gareth Leng,Mike Ludwig +1 more
TL;DR: Effects of intranasal oxytocin also need proper dose-response studies, and such studies need to include control subjects for peripheral effects, by administering Oxytocin peripherally and by blocking peripheral actions with antagonists.
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Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
TL;DR: It is shown that in hypothalamic oxytocin neurons, agents that mobilize intracellular Ca2+ induce oxytoc in release from dendrites without increasing the electrical activity of the cell body, and without inducing secretion from the nerve terminals.
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Dendritic Release of Vasopressin and Oxytocin
TL;DR: Spatial and temporal differences between peptide release within the nuclei and that from the distant axonal varicosities indicate that the release mechanisms are at least partially independent, supporting the hypothesis of locally regulated dendritic release of vasopressin and oxytocin.
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Behavioral consequences of intracerebral vasopressin and oxytocin : Focus on learning and memory
TL;DR: It is suggested that, depending on the behavioral test and the brain area under study, these endogenous neuropeptides are differentially involved in behavioral regulation; thus, generalizations derived from a single behavioral task should be avoided.