Mikell Paige

TL;DR: Sazetidine-A significantly reduced alcohol and nicotine intake in P rats that self-administer higher levels of both drugs and may hold promise for the treatment of alcohol and Nicotine addiction.

TL;DR: This study identified a boronic acid chalcone with inhibition towards 16 human cancer cell lines in the 10-200nM range, and another three cell lines with GI(50)-values below 10nM, which has significant anti-angiogenesis effects demonstrated by HUVEC tube formation and aortic ring assay.

TL;DR: Very low doses of sazetidine-A or drugs with a similar profile may provide therapeutic benefit for reversing attentional impairment in patients suffering from mental disorders and/or cognitive impairment, and imply an important role for α4β2 nicotinic receptors in improving sustained attention under conditions that disrupt it.

TL;DR: The continuing effectiveness of sazetidine-A in reducing nicotine self-administration in both male and female rats supports its promise as a new treatment to help people successfully quit smoking.

TL;DR: A fluorescent lead compound up-regulated RASSF1A in vitro, potently inhibited human prostate cancer cell proliferation, and fluoresced at a visible wavelength, allowing for the observation of intracellular distribution.