M
Mikhail V. Chernov
Researcher at Roswell Park Cancer Institute
Publications - 21
Citations - 3189
Mikhail V. Chernov is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Transactivation & Phosphorylation. The author has an hindex of 15, co-authored 21 publications receiving 3009 citations. Previous affiliations of Mikhail V. Chernov include Cleveland Clinic Lerner Research Institute & Cleveland Clinic.
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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Pavel G. Komarov,Elena A. Komarova,Roman V. Kondratov,Konstantin Christov-Tselkov,John S. Coon,Mikhail V. Chernov,Andrei V. Gudkov +6 more
TL;DR: This study has shown that a small molecule isolated for its ability to reversibly block p53-dependent transcriptional activation and apoptosis protected mice from the lethal genotoxic stress associated with anticancer treatment without promoting the formation of tumors.
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The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control
Igor Garkavtsev,Irina A. Grigorian,Ossovskaya Valeria S,Ossovskaya Valeria S,Mikhail V. Chernov,Peter M. Chumakov,Andrei V. Gudkov +6 more
TL;DR: The results indicate that p33ING1 is a component of the p53 signalling pathway that cooperates with p53 in the negative regulation of cell proliferation by modulating p53-dependent transcriptional activation.
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Regulation of c‐myc expression by IFN‐γ through Stat1‐dependent and ‐independent pathways
Chilakamarti V. Ramana,Nicholas Grammatikakis,Nicholas Grammatikakis,Mikhail V. Chernov,Hannah Nguyen,Kee Chuan Goh,Bryan R.G. Williams,George R. Stark +7 more
TL;DR: A role for Raf‐1 in the Stat1‐independent pathway is revealed by studies with geldanamycin, an H SP90‐specific inhibitor, and by expression of a mutant of p50cdc37 that is unable to recruit HSP90 to the Raf‐ 1 complex, which abrogated the IFN‐γ‐dependent induction of c‐myc expression in Stat1-null cells.
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Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
Elena A. Komarova,Mikhail V. Chernov,Roberta Franks,Kaihua Wang,Gabriella Armin,Carolyn R. Zelnick,Dot Chin,Sarah S. Bacus,George R. Stark,Andrei V. Gudkov +9 more
TL;DR: The data suggest that p53 activity, monitored by the reporter lacZ transgene, is the determinant of radiation and drug sensitivity in vivo and indicate the importance of tissue and stage specificity of p53 regulation at the level of mRNA expression.
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BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
Roman V. Kondratov,Mikhail V. Chernov,Anna A. Kondratova,Victoria Gorbacheva,Andrei V. Gudkov,Marina P. Antoch +5 more
TL;DR: Results provide evidence for an additional level of circadian system control, which is based on regulation of transcriptional activity or/and availability of CLOCK/BMAL1 complex, and all posttranslational events described in this study are coupled with active transactivation complex formation, which argues for their significant functional role.