R
Roman V. Kondratov
Researcher at Cleveland State University
Publications - 57
Citations - 6321
Roman V. Kondratov is an academic researcher from Cleveland State University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 32, co-authored 55 publications receiving 5542 citations. Previous affiliations of Roman V. Kondratov include University of Illinois at Chicago & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Pavel G. Komarov,Elena A. Komarova,Roman V. Kondratov,Konstantin Christov-Tselkov,John S. Coon,Mikhail V. Chernov,Andrei V. Gudkov +6 more
TL;DR: This study has shown that a small molecule isolated for its ability to reversibly block p53-dependent transcriptional activation and apoptosis protected mice from the lethal genotoxic stress associated with anticancer treatment without promoting the formation of tumors.
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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
Roman V. Kondratov,Anna A. Kondratova,Victoria Gorbacheva,Olena Vykhovanets,Marina P. Antoch +4 more
TL;DR: It is reported that Bmal1(-/-) mice have reduced lifespans and display various symptoms of premature aging including sarcopenia, cataracts, less subcutaneous fat, organ shrinkage, and others.
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The circadian clock and pathology of the ageing brain
TL;DR: New data from experiments in model organisms, gene expression studies and clinical trials imply that dysfunctions of the circadian clock contribute to ageing and age-associated pathologies, thereby suggesting a functional link between the circadian Clock andAge-associated decline of brain functions.
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Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Darwin Jeyaraj,Saptarsi M. Haldar,Xiaoping Wan,Mark McCauley,Juergen Ripperger,Kun Hu,Yuan Lu,Betty L. Eapen,Nikunj Sharma,Eckhard Ficker,Michael J. Cutler,James Gulick,Atsushi Sanbe,Jeffrey M. Robbins,Sophie Demolombe,Roman V. Kondratov,Steven Shea,Urs Albrecht,Xander H.T. Wehrens,David S. Rosenbaum,Mukesh K. Jain +20 more
TL;DR: Findings identify circadian transcription of ion channels as a mechanism for cardiac arrhythmogenesis through endogenous circadian rhythmicity under the control of a clock-dependent oscillator, krüppel-like factor 15 (Klf15).
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Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
Victoria Gorbacheva,Roman V. Kondratov,Renliang Zhang,Srujana Cherukuri,Andrei V. Gudkov,Joseph S. Takahashi,Marina P. Antoch +6 more
TL;DR: It is proposed that the CLOCK/BMAL1 transcriptional complex affects the lethality of chemotherapeutic agents by modulating the survival of the target cells necessary for the viability of the organism.