M
Mikiko C. Siomi
Researcher at University of Tokyo
Publications - 112
Citations - 16906
Mikiko C. Siomi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 47, co-authored 106 publications receiving 15515 citations. Previous affiliations of Mikiko C. Siomi include Keio University & University of Pennsylvania.
Papers
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Journal ArticleDOI
Biogenesis of small RNAs in animals.
TL;DR: This Review summarizes the current knowledge of how these intriguing molecules are generated in animal cells.
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PIWI-interacting small RNAs: the vanguard of genome defence.
TL;DR: Owing to their limited expression in gonads and their sequence diversity, piRNAs have been the most mysterious class of small non-coding RNAs regulating RNA silencing, but much progress is being made into the understanding of their biogenesis and molecular functions, including the specific subcellular compartmentalization of the piRNA pathway in granular cytoplasmic bodies.
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A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila.
Lalith S. Gunawardane,Kuniaki Saito,Kazumichi M. Nishida,Keita Miyoshi,Yoshinori Kawamura,Tomoko Nagami,Haruhiko Siomi,Mikiko C. Siomi +7 more
TL;DR: Sequenced small RNAs associated with the PIWI subfamily member AGO3 support a model in which formation of a 5′ terminus within rasiRNA precursors is guided by rasiRNAs originating from transcripts of the other strand in concert with the Slicer activity of PIWI.
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Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
TL;DR: It is shown that AGO2 is an essential component for siRNA-directed RNA interference (RNAi) response and is required for the unwinding of siRNA duplex and in consequence assembly of si RNA into RISC in Drosophila embryos, and that distinct Argonaute proteins act at different steps of the small RNA silencing mechanism.
Journal ArticleDOI
On the road to reading the RNA-interference code.
Haruhiko Siomi,Mikiko C. Siomi +1 more
TL;DR: The finding that sequence-specific gene silencing occurs in response to the presence of double-stranded RNAs has had an enormous impact on biology, uncovering an unsuspected level of regulation of gene expression.