J
Jinju Han
Researcher at KAIST
Publications - 25
Citations - 19488
Jinju Han is an academic researcher from KAIST. The author has contributed to research in topics: microRNA & Drosha. The author has an hindex of 17, co-authored 22 publications receiving 18270 citations. Previous affiliations of Jinju Han include Seoul National University & Salk Institute for Biological Studies.
Papers
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Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
Journal ArticleDOI
MicroRNA genes are transcribed by RNA polymerase II.
TL;DR: The first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II) is presented and the detailed structure of a miRNA gene is described, for the first time, by determining the promoter and the terminator of mir‐23a∼27a‐24‐2.
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Biogenesis of small RNAs in animals.
TL;DR: This Review summarizes the current knowledge of how these intriguing molecules are generated in animal cells.
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The Drosha-DGCR8 complex in primary microRNA processing
TL;DR: It is shown that DGCR8 may be an essential component of the pri-miRNA processing complex, along with Drosha, and a model for the action mechanism of class II RNase III proteins is proposed.
Journal ArticleDOI
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
Jinju Han,Yoontae Lee,Kyu-Hyeon Yeom,Jin Wu Nam,Inha Heo,Je-Keun Rhee,Sun Young Sohn,Yunje Cho,Byoung-Tak Zhang,V. Narry Kim +9 more
TL;DR: DGCR8 may function as the molecular anchor that measures the distance from the dsRNA-ssRNA junction and facilitate the prediction of novel microRNAs and will assist in the rational design of small hairpin RNAs for RNA interference.