M
Mikiko Tohyama
Researcher at Ehime University
Publications - 127
Citations - 3897
Mikiko Tohyama is an academic researcher from Ehime University. The author has contributed to research in topics: Keratinocyte & Toxic epidermal necrolysis. The author has an hindex of 32, co-authored 120 publications receiving 3457 citations.
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Journal ArticleDOI
Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37
Sho Tokumaru,Koji Sayama,Yuji Shirakata,Hitoshi Komatsuzawa,Kazuhisa Ouhara,Yasushi Hanakawa,Yoko Yahata,Xiuju Dai,Mikiko Tohyama,Hiroshi Nagai,Lujun Yang,Shigeki Higashiyama,Akihiko Yoshimura,Motoyuki Sugai,Koji Hashimoto +14 more
TL;DR: It is suggested that LL-37 closes skin wounds by the induction of keratinocyte migration via heparin-binding-EGF-mediated transactivation of EGFR, and SOCS1/Jak2 binding protein or SOCS3/CIS3 negatively regulate this migration.
Journal ArticleDOI
Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome
Mikiko Tohyama,Koji Hashimoto,Masaki Yasukawa,Hiroshi Kimura,Tatsuya Horikawa,K. Nakajima,Y. Urano,Kazuhiko Matsumoto,Masafumi Iijima,N.H. Shear +9 more
TL;DR: The association of human herpesvirus (HHV)‐6 reactivation with DIHS has been reported and the causative drugs for DIHS are limited to the following eight.
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Severe Hypersensitivity Syndrome Due to Sulfasalazine Associated With Reactivation of Human Herpesvirus 6
Mikiko Tohyama,Yoko Yahata,Masaki Yasukawa,Reiko Inagi,Yoshio Urano,Koichi Yamanishi,Koji Hashimoto +6 more
TL;DR: Two cases of hypersensitivity syndrome due to sulfasalazine use were associated with the reactivation of human herpesvirus 6, which may be a required cause of hypers sensitivity syndrome.
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Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome
TL;DR: Reactivation of human herpesvirus (HHV)‐6 has been reported in patients with DIHS, and some other DIHS patients showed reactivation of cytomegalovirus (CMV) or Epstein–Barr virus (EBV).
Journal ArticleDOI
Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes
Xiuju Dai,Koji Sayama,Mikiko Tohyama,Yuji Shirakata,Yasushi Hanakawa,Sho Tokumaru,Lujun Yang,Satoshi Hirakawa,Koji Hashimoto +8 more
TL;DR: House dust mite allergens are danger signals for the skin and HDM-induced activation of the NLRP3 inflammasome may play a pivotal role in the pathogenesis of AD.