M
Mikio Furuse
Researcher at Graduate University for Advanced Studies
Publications - 165
Citations - 35651
Mikio Furuse is an academic researcher from Graduate University for Advanced Studies. The author has contributed to research in topics: Tight junction & Claudin. The author has an hindex of 69, co-authored 155 publications receiving 33025 citations. Previous affiliations of Mikio Furuse include Harvard University & Kobe University.
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Occludin: a novel integral membrane protein localizing at tight junctions.
TL;DR: An integral membrane protein localizing at tight junctions is now identified, which is designated as "occludin," which was revealed by a hydrophilicity plot that was very similar to that of connexin, an integral membraneprotein in gap junctions.
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Multifunctional strands in tight junctions.
TL;DR: New insights into the molecular architecture of tight junctions allow us to now discuss the structure and functions of this unique cell–cell adhesion apparatus in molecular terms.
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Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin
TL;DR: It is indicated that multiple integral membrane proteins with four putative transmembrane domains, occludin and claudins, constitute TJ strands.
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Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice
Takehiro Nitta,Masaki Hata,Shimpei Gotoh,Yoshiteru Seo,Hiroyuki Sasaki,Nobuo Hashimoto,Mikio Furuse,Shoichiro Tsukita +7 more
TL;DR: In claudin-5–deficient mice, the size-selective loosening of the blood-brain barrier was selectively affected, which provides new insight into the basic molecular physiology of BBB and opens a new way to deliver potential drugs across the BBB into the central nervous system.
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Claudin-based tight junctions are crucial for the mammalian epidermal barrier a lesson from claudin-1–deficient mice
Mikio Furuse,Masaki Hata,Kyoko Furuse,Yoko Yoshida,Akinori Haratake,Yoshinobu Sugitani,Tetsuo Noda,Tetsuo Noda,Akiharu Kubo,Shoichiro Tsukita +9 more
TL;DR: Findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin.