Y
Yoshinobu Sugitani
Researcher at Japanese Foundation for Cancer Research
Publications - 25
Citations - 3589
Yoshinobu Sugitani is an academic researcher from Japanese Foundation for Cancer Research. The author has contributed to research in topics: Medicine & Mutant. The author has an hindex of 19, co-authored 21 publications receiving 3319 citations. Previous affiliations of Yoshinobu Sugitani include Cancer Research Institute & RIKEN Brain Science Institute.
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Journal ArticleDOI
Claudin-based tight junctions are crucial for the mammalian epidermal barrier a lesson from claudin-1–deficient mice
Mikio Furuse,Masaki Hata,Kyoko Furuse,Yoko Yoshida,Akinori Haratake,Yoshinobu Sugitani,Tetsuo Noda,Tetsuo Noda,Akiharu Kubo,Shoichiro Tsukita +9 more
TL;DR: Findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin.
Journal ArticleDOI
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.
Yoshinobu Sugitani,Shigeyasu Nakai,Osamu Minowa,Miyuki Nishi,Kou-ichi Jishage,Hitoshi Kawano,Kensaku Mori,Masaharu Ogawa,Tetsuo Noda +8 more
TL;DR: It is shown that double disruption of both Brn-1 andBrn-2 genes in mice leads to abnormal formation of the neocortex with dramatically reduced production of layer IV-II neurons and defective migration of neurons unable to express mDab1.
Journal ArticleDOI
Lack of acrosome formation in mice lacking a Golgi protein, GOPC.
Ryoji Yao,Chizuru Ito,Yasuko Natsume,Yoshinobu Sugitani,Hitomi Yamanaka,Shoji Kuretake,Kaoru Yanagida,Akira Sato,Kiyotaka Toshimori,Tetsuo Noda +9 more
TL;DR: Golgi-associated PDZ- and coiled-coil motif-containing protein (GOPC) provides important clues to understanding the mechanisms underlying spermatogenesis, and the GOPC-deficient mouse may be a unique and valuable model for human globozoospermia.
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A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
Toshiyuki Kobayashi,Osamu Minowa,Yoshinobu Sugitani,Setsuo Takai,Hiroaki Mitani,Etsuko Kobayashi,Tetsuo Noda,Okio Hino +7 more
TL;DR: The Tsc1 knockout mouse described here will be a useful model to elucidate the function of TSC1 and Tsc2 products as well as pathogenesis of TS.
Journal ArticleDOI
Altered Cochlear Fibrocytes in a Mouse Model of DFN3 Nonsyndromic Deafness
Osamu Minowa,Katsuhisa Ikeda,Yoshinobu Sugitani,Takeshi Oshima,Shigeyasu Nakai,Yukio Katori,Masaaki Suzuki,Masayuki Furukawa,Tetsuaki Kawase,Y. Zheng,Masaki Ogura,Yukinori Asada,Kenichi Watanabe,Hitomi Yamanaka,S. Gotoh,S. Gotoh,M. Nishi-Takeshima,Tetsuo Sugimoto,Toshiaki Kikuchi,Tomonori Takasaka,Tetsuo Noda,Tetsuo Noda +21 more
TL;DR: The findings suggest that cochlear spiral ligament fibrocytes, which are mesenchymal in origin and for which a role in potassium ion homeostasis has been postulated, may play a critical role in auditory function.