M
Mikolaj Zmudzinski
Researcher at Wrocław University of Technology
Publications - 16
Citations - 809
Mikolaj Zmudzinski is an academic researcher from Wrocław University of Technology. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 8, co-authored 9 publications receiving 455 citations.
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Journal ArticleDOI
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repurposing.
Journal ArticleDOI
SARS-CoV-2 M pro inhibitors and activity-based probes for patient-sample imaging
Wioletta Rut,Katarzyna Groborz,Linlin Zhang,Xinyuanyuan Sun,Mikolaj Zmudzinski,Bartlomiej Pawlik,Bartlomiej Pawlik,Xinyu Wang,Dirk Jochmans,Johan Neyts,Wojciech Młynarski,Rolf Hilgenfeld,Marcin Drag +12 more
TL;DR: A combinatorial library of fluorogenic substrates with glutamine in the P1 position is synthesized and provided a structural framework for the design of inhibitors as antiviral agents and/or diagnostic tests.
Posted ContentDOI
Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repositioning.
Posted ContentDOI
Activity profiling of SARS-CoV-2-PLpro protease provides structural framework for anti-COVID-19 drug design
Wioletta Rut,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Miklós Békés,Tony T. Huang,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: The molecular rules governing PLpro substrate specificity are revealed and a framework for development of inhibitors with potential therapeutic value or drug repositioning is provided and designed optimal fluorogenic substrates and irreversible inhibitors with a high degree of selectivity for SARS PLpro variants versus other proteases.
Posted ContentDOI
Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design
Wioletta Rut,Katarzyna Groborz,Linlin Zhang,Xinyuanyuan Sun,Mikolaj Zmudzinski,Bartlomiej Pawlik,Wojciech Mlynarski,Rolf Hilgenfeld,Marcin Drag +8 more
TL;DR: A combinatorial library of fluorogenic substrates with glutamine in the P1 position is synthesized and provided a structural framework for the design of inhibitors as antiviral agents or diagnostic tests.