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Stephanie Patchett
Researcher at New York University
Publications - 4
Citations - 465
Stephanie Patchett is an academic researcher from New York University. The author has contributed to research in topics: Deubiquitinating enzyme & Coronavirus. The author has an hindex of 3, co-authored 4 publications receiving 258 citations. Previous affiliations of Stephanie Patchett include Medical University of South Carolina & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repurposing.
Posted ContentDOI
Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repositioning.
Posted ContentDOI
Activity profiling of SARS-CoV-2-PLpro protease provides structural framework for anti-COVID-19 drug design
Wioletta Rut,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Miklós Békés,Tony T. Huang,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: The molecular rules governing PLpro substrate specificity are revealed and a framework for development of inhibitors with potential therapeutic value or drug repositioning is provided and designed optimal fluorogenic substrates and irreversible inhibitors with a high degree of selectivity for SARS PLpro variants versus other proteases.
Journal ArticleDOI
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease.
Stephanie Patchett,Zongyang Lv,Wioletta Rut,Miklós Békés,Marcin Drag,Shaun K. Olsen,Tony T. Huang +6 more
TL;DR: In this paper, the SARS-CoV-2 papain-like protease (PLpro) was identified as a potential hotspot of variability that could alter host antiviral immune responses.