M
Marcin Drag
Researcher at Wrocław University of Technology
Publications - 158
Citations - 5789
Marcin Drag is an academic researcher from Wrocław University of Technology. The author has contributed to research in topics: Protease & Proteases. The author has an hindex of 42, co-authored 141 publications receiving 4621 citations. Previous affiliations of Marcin Drag include Centre national de la recherche scientifique & École nationale supérieure de chimie de Montpellier.
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Journal ArticleDOI
Emerging principles in protease-based drug discovery
Marcin Drag,Guy S. Salvesen +1 more
TL;DR: The general principles in protease-based drug discovery are discussed, highlighting the lessons learned and the emerging strategies, such as targeting allosteric sites, which could help harness the therapeutic potential of new protease targets.
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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Wioletta Rut,Zongyang Lv,Zongyang Lv,Mikolaj Zmudzinski,Stephanie Patchett,Digant Nayak,Digant Nayak,Scott J. Snipas,Farid El Oualid,Tony T. Huang,Miklós Békés,Marcin Drag,Marcin Drag,Shaun K. Olsen,Shaun K. Olsen +14 more
TL;DR: This work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential therapeutic value or drug repurposing.
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FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
Cristina Pop,Andrew Oberst,Marcin Drag,Marcin Drag,Bram J. van Raam,Stefan J. Riedl,Douglas R. Green,Guy S. Salvesen +7 more
TL;DR: It is demonstrated that cleavage of the catalytic domain of caspase 8 is crucial for its activity in the context of activation by homodimerization, and use of FLIP(L) as a partner for caspases 8 in dimerization-induced activation rescues the requirement for intersubunit linker proteolysis in both protomers.
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SARS-CoV-2 M pro inhibitors and activity-based probes for patient-sample imaging
Wioletta Rut,Katarzyna Groborz,Linlin Zhang,Xinyuanyuan Sun,Mikolaj Zmudzinski,Bartlomiej Pawlik,Bartlomiej Pawlik,Xinyu Wang,Dirk Jochmans,Johan Neyts,Wojciech Młynarski,Rolf Hilgenfeld,Marcin Drag +12 more
TL;DR: A combinatorial library of fluorogenic substrates with glutamine in the P1 position is synthesized and provided a structural framework for the design of inhibitors as antiviral agents and/or diagnostic tests.
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Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs.
Jowita Mikolajczyk,Marcin Drag,Marcin Drag,Miklós Békés,Miklós Békés,John T. Cao,Ze'ev Ronai,Guy S. Salvesen +7 more
TL;DR: Using purified recombinant catalytic domains of 6 of the 7 human SENPs, it is revealed that the SUMO domain enhances catalysis of SENP1, -2, -5, -6, and -7, demonstrating substrate-induced activation of SENPs by SUMOs.