M
Milada S. Vala
Researcher at Johns Hopkins University
Publications - 23
Citations - 1943
Milada S. Vala is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 16, co-authored 23 publications receiving 1882 citations. Previous affiliations of Milada S. Vala include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents
Atul Bedi,James Barber,Gauri C. Bedi,Wafik S. El-Deiry,David Sidransky,Milada S. Vala,Adil J. Akhtar,John Hilton,Richard J. Jones +8 more
TL;DR: The inherent resistance of human cancers to genotoxic agents may result not only by the loss or inactivation of the wild-type p53 gene, but also by genetic alterations such as BCR-ABL that can delay G2/M transition after DNA damage.
Journal ArticleDOI
Assessment of aldehyde dehydrogenase in viable cells
Richard J. Jones,James Barber,Milada S. Vala,Michael I. Collector,Scott H. Kaufmann,S M Ludeman,O M Colvin,John Hilton +7 more
TL;DR: The ability to isolate viable cells that express high levels of cytosolic ALDH could be an important component of methodology for identifying and purifying HSC and for studying cyclophosphamide-resistant tumor cell populations.
Journal ArticleDOI
A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia.
Jonathan M. Gerber,B. Douglas Smith,Brownhilda Ngwang,Hao Zhang,Milada S. Vala,Laura Morsberger,Steven Galkin,Michael I. Collector,Brandy Perkins,Mark J. Levis,Constance A. Griffin,Saul J. Sharkis,Michael J. Borowitz,Judith E. Karp,Richard J. Jones +14 more
TL;DR: Minimal residual disease detected during complete remission was enriched for the CD34(+)CD38(-)ALDH(int) leukemic cells, and the presence of these cells after therapy highly correlated with subsequent clinical relapse.
Journal ArticleDOI
Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity
Richard J. Jones,Michael I. Collector,James Barber,Milada S. Vala,MJ Fackler,WS May,Constance A. Griffin,Anita L. Hawkins,Barbara A. Zehnbauer,John Hilton,O M Colvin,Saul J. Sharkis +11 more
TL;DR: It is shown that 10 LHSC can generate all blood cell lineages for the lifetime of the animal, however, these cells lacked radioprotection and spleen colony-forming activity.
Journal ArticleDOI
Circulating clonotypic B cells in classic Hodgkin lymphoma.
Richard J. Jones,Christopher D. Gocke,Yvette L. Kasamon,Carole B. Miller,Brandy Perkins,James Barber,Milada S. Vala,Jonathan M. Gerber,Lan L. Gellert,Mark J. Siedner,M. Victor Lemas,Sarah Brennan,Richard F. Ambinder,William Matsui +13 more
TL;DR: It is found that both the L428 and KM-H2 HL cell lines contained rare B-cell subpopulations responsible for the generation and maintenance of the predominant HRS cell population.