M
Min Dong
Researcher at Boston Children's Hospital
Publications - 123
Citations - 4924
Min Dong is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 29, co-authored 99 publications receiving 3831 citations. Previous affiliations of Min Dong include Harvard University & Children's Medical Center of Dallas.
Papers
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Journal ArticleDOI
SV2 is the protein receptor for botulinum neurotoxin A.
Min Dong,Felix L. Yeh,William H. Tepp,Camin Dean,Eric A. Johnson,Roger Janz,Edwin R. Chapman +6 more
TL;DR: It is found that BoNT/A enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C), and SV2 acts as the protein receptor for Bo NT/A.
Journal ArticleDOI
Massively parallel de novo protein design for targeted therapeutics
Aaron Chevalier,Daniel-Adriano Silva,Gabriel J. Rocklin,Derrick R. Hicks,Renan Vergara,Renan Vergara,Patience Murapa,Steffen M. Bernard,Lu Zhang,Lu Zhang,Kwok-Ho Lam,Guorui Yao,Christopher D. Bahl,Shin-Ichiro Miyashita,Shin-Ichiro Miyashita,Inna Goreshnik,James T. Fuller,Merika Treants Koday,Cody M. Jenkins,Tom Colvin,Lauren Carter,Alan J. Bohn,Cassie M. Bryan,D. Alejandro Fernández-Velasco,Lance Stewart,Min Dong,Min Dong,Xuhui Huang,Rongsheng Jin,Ian A. Wilson,Deborah H. Fuller,David Baker +31 more
TL;DR: A massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing is described.
Journal ArticleDOI
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
Min Dong,David Richards,Michael C. Goodnough,William H. Tepp,Eric A. Johnson,Edwin R. Chapman +5 more
TL;DR: It is reported here that the secretory vesicle proteins, synaptotagmins (syts) I and II, mediate the entry of BoNT/B into PC12 cells and rat diaphragm motor nerve terminals and shown that syt II fragments, in conjunction with gangliosides, neutralized Bo NT/B in intact mice.
Journal ArticleDOI
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
TL;DR: It is demonstrated that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.
Journal ArticleDOI
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Qing Chai,Joseph W. Arndt,Min Dong,William H. Tepp,Eric A. Johnson,Edwin R. Chapman,Raymond C. Stevens +6 more
TL;DR: The crystal structure of full-length BoNT/B in complex with the synaptotagmin II (Syt-II) recognition domain is reported and provides structural insights into how BoNTs recognize protein receptors and reveals a promising target for blocking toxin–receptor recognition.