Min Gao

TL;DR: Inhibition of NS5B activity by RNA template exhibited characteristics of substrate inhibition, suggesting the template binds to a secondary site on the enzyme forming an inactive complex, and template inhibition was modulated by primer.

TL;DR: In this article , the authors show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.

TL;DR: Comparison of co-crystal structures of a potent analog with both NS5B genotypes 1a and genotype 1b provides a possible explanation for the genotype-selectivity observed with this compound class and suggests opportunities for the further optimization of the series.

TL;DR: In this article, the authors presented a dual HCV assay useful for high-throughput screening that quantifies both the amount of HCV RNA replication inhibitory activity associated with a test compound and its cytotoxicity associated with that test compound.

TL;DR: This is the first report that demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo, suggesting that the additional pharmacology of BMS-986318 does not further benefit efficacy, possibly presenting an opportunity for reduced adverse effects.