L
Lei Gao
Researcher at Beckman Research Institute
Publications - 12
Citations - 579
Lei Gao is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications receiving 138 citations. Previous affiliations of Lei Gao include City of Hope National Medical Center & Houston Methodist Hospital.
Papers
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Journal ArticleDOI
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Rui Su,Lei Dong,Yangchan Li,Min Gao,Li Han,Mark Wunderlich,Xiaolan Deng,Hongzhi Li,Yue Huang,Lei Gao,Chenying Li,Zhicong Zhao,Sean Robinson,Brandon Tan,Ying Qing,Xi Qin,Emily Prince,Jun Xie,Hanjun Qin,Wei Li,Chao Shen,Jie Sun,Prakash Kulkarni,Hengyou Weng,Huilin Huang,Zhenhua Chen,Bin Zhang,Xiwei Wu,Mark Olsen,Markus Müschen,Guido Marcucci,Guido Marcucci,Ravi Salgia,Ling Li,Ling Li,Amir T. Fathi,Zejuan Li,James C. Mulloy,Minjie Wei,David Horne,Jianjun Chen,Jianjun Chen +41 more
TL;DR: It is shown that genetic depletion and pharmacological inhibition of FTO dramatically attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppressing expression of immune checkpoint genes, especially LILRB4.
Journal ArticleDOI
R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis.
Ying Qing,Ying Qing,Lei Dong,Lei Gao,Lei Gao,Chenying Li,Chenying Li,Yangchan Li,Yangchan Li,Li Han,Li Han,Emily Prince,Brandon Tan,Xiaolan Deng,Collin Wetzel,Chao Shen,Min Gao,Min Gao,Zhenhua Chen,Wei Li,Bin Zhang,Bin Zhang,Daniel Braas,Johanna ten Hoeve,Gerardo Javier Sanchez,Huiying Chen,Lai N. Chan,Lai N. Chan,Chun-Wei Chen,Chun-Wei Chen,David K. Ann,Lei Jiang,Markus Müschen,Markus Müschen,Markus Müschen,Guido Marcucci,Guido Marcucci,David R. Plas,Zejuan Li,Rui Su,Jianjun Chen,Jianjun Chen +41 more
TL;DR: This paper showed that R-2-hydroxyglutarate (R-2HG) effectively attenuates aerobic glycolysis, a hallmark of cancer metabolism, in (R 2HG-sensitive) leukemia cells, but not in normal CD34+ hematopoietic stem/progenitor cells.
Journal ArticleDOI
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
Rui Su,Lei Dong,Yangchan Li,Min Gao,P. Cody He,Wei Li,Jiangbo Wei,Zhi-Ning Zhao,Lei Gao,Lijuan Han,Xiaolan Deng,Chenying Li,Emily Prince,Brandon Tan,Ying Qing,Xi Qin,Chao Shen,Meilin Xue,Keren Zhou,Zhenhua Chen,Jingling Xue,Wei Li,Hanjun Qin,Xiwei Wu,Miao Sun,Yunsun Nam,Chun-Wei Chen,Wendong Huang,David J. Horne,Steven T. Rosen,Chuan He,Jianjun Chen +31 more
TL;DR: In this article , the authors show that METTL16 exerts both methyltransferase activity-dependent and -independent functions in gene regulation in the cell nucleus and in the cytosol.
Journal ArticleDOI
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Lijuan Han,Lei Dong,Keith Chin-Kee Leung,Zhi-Ning Zhao,Yangchan Li,Lei Gao,Zhenhua Chen,Jingling Xue,Ying Qing,Wei Li,Sheela Pangeni Pokharel,Min Gao,Meiling Chen,Chao Shen,Brandon Tan,Andrew M. Small,Kitty Wan Ching Wang,Zheng-Zhong Zhang,Xi Qin,Lucie Yang,Mark Wunderlich,Bin Amber Zhang,James C. Mulloy,Guido Marcucci,Chun-Wei Chen,Minjie Wei,Rui Su,Jianjun Chen,Xiaolan Deng +28 more
TL;DR: In this article , the authors show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.
Journal ArticleDOI
Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance
Rui Su,Lei Dong,Yangchan Li,Li Han,Min Gao,Mark Wunderlich,Xiaolan Deng,Hongzhi Li,Lei Gao,Chenying Li,Sean Robison,Brandon Tan,Ying Qing,Xi Qin,Emily Prince,Jun Xie,Hanjun Qin,Yue Huang,Wei Li,Chao Shen,Jie Sun,Kulkarni Prakash,Hengyou Weng,Huilin Huang,Zhenhua Chen,Bin Zhang,Xiwei Wu,Mark Olsen,Markus Müschen,Guido Marcucci,Salgia Ravi,Ling Li,Cai-Guang Yang,Zejuan Li,James C. Mulloy,Minjie Wei,David Horne,Jianjun Chen +37 more
TL;DR: The data suggest that FTO is a promising and druggable target in leukemia and two compounds, namely CS1 and CS2, displayed consistently potent anti-leukemic effects in all the AML cell lines the authors tested, and also showed the most significant effects on inhibition of FTO's m6A demethylase activity.