M
Min-Tsang Hsieh
Researcher at China Medical University (Taiwan)
Publications - 42
Citations - 319
Min-Tsang Hsieh is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Catalysis & Michael reaction. The author has an hindex of 10, co-authored 38 publications receiving 250 citations. Previous affiliations of Min-Tsang Hsieh include China Medical University (PRC) & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Solvent- and Transition Metal Catalyst-Dependent Regioselectivity in the [3+2] Cyclocondensation of Trifluoromethyl-α,β-ynones with Hydrazines: Switchable Access to 3- and 5-Trifluoromethylpyrazoles
TL;DR: The title cyclocondensation reaction gives 3-trifluoromethylpyrazoles with high regioselectivity in the presence of Cu(OAc)2 in CH2Cl2 as mentioned in this paper.
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YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK.
Ling-Chu Chang,Hui-Yi Lin,Meng Tung Tsai,Ruey Hwang Chou,Ruey Hwang Chou,Fang Yu Lee,Che-Ming Teng,Min-Tsang Hsieh,Hsin Yi Hung,Li-Jiau Huang,Yung Luen Yu,Yung Luen Yu,Sheng-Chu Kuo +12 more
TL;DR: This work investigated the in vivo antitumour efficacy of YC‐1 in an MDA‐MB‐468 xenograft model and elucidated the mechanism of down‐regulation of enhancer of zeste homology 2 (EZH2) by YC-1 in breast cancer cells.
Journal ArticleDOI
Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study
Ling-Chu Chang,Min-Tsang Hsieh,Jai Sing Yang,Chi Cheng Lu,Fuu Jen Tsai,Je Wei Tsao,Yu Jen Chiu,Sheng-Chu Kuo,Kuo Hsiung Lee +8 more
TL;DR: The results suggest that MTH-3 might be a novel therapeutic agent for the treatment of triple-negative breast cancer in the near future.
Journal ArticleDOI
The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells.
Min-Tsang Hsieh,Hao-Ping Chen,Chi Cheng Lu,Jo Hua Chiang,Tian Shung Wu,Daih Huang Kuo,Li-Jiau Huang,Sheng-Chu Kuo,Jai Sing Yang +8 more
TL;DR: Results presented in this study show that ANK-199 may become a novel therapeutic reagent for the treatment of oral cancer in the near future (patent pending).
Journal ArticleDOI
New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo
Min-Tsang Hsieh,Ling-Chu Chang,Hsin Yi Hung,Hui-Yi Lin,Mei Hui Shih,Chang Hai Tsai,Sheng-Chu Kuo,Kuo Hsiung Lee,Kuo Hsiung Lee +8 more
TL;DR: Novel bis(hydroxymethyl) alkanoate curcuminoid derivatives were designed, synthesized and screened for in-vitro antiproliferative and in vivo antitumor activity and compound 9a exhibited greater inhibitory activity thanCurcumin against TNBC cells and also demonstrated significant inhibitoryActivity against doxorubicin-resistant MDA-MB-231 cells, with ten-fold higher potency than curcuming.