M
Minhtam Doan
Publications - 2
Citations - 1897
Minhtam Doan is an academic researcher. The author has contributed to research in topics: Amyloid precursor protein & Cleavage (embryo). The author has an hindex of 2, co-authored 2 publications receiving 1843 citations.
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Journal ArticleDOI
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sukanto Sinha,John P. Anderson,Robin Barbour,Guriqbal S. Basi,Russell J. Caccavello,David Davis,Minhtam Doan,Harry F. Dovey,Normand Frigon,Jin Hong,Kirsten L. Jacobson-Croak,Nancy Jewett,Pamela S. Keim,J. Knops,Ivan Lieberburg,Michael Power,Hua Tan,Gwen Tatsuno,Jay Tung,Dale Schenk,Peter Seubert,Susanna Suomensaari,Shuwen Wang,Donald A. Walker,Jun Zhao,Lisa McConlogue,Varghese John +26 more
TL;DR: A membrane-bound enzyme activity that cleaves full-length APP at the β-secretase cleavage site is described and found to be the predominant β-cleavage activity in human brain, and it is found that human brain β- secretase is a new membrane- bound aspartic proteinase.
Journal ArticleDOI
Immunotherapy reduces vascular amyloid-beta in PDAPP mice.
Sally Schroeter,Karen Khan,Robin Barbour,Minhtam Doan,Ming Chen,Terry Guido,Gill Davinder,Guriqbal S. Basi,Dale Schenk,Peter Seubert,Dora Games +10 more
TL;DR: The results suggest that passive immunization can reduce VAβ levels, and modulating antibody dose can significantly mitigate the incidence of microhemorrhage while still preventing or reducing VAβ.