Miquel Martin

TL;DR: Findings demonstrate that endogenous cannabinoids through the activation of CB1 receptors are implicated in the control of emotional behaviour and participate in the physiological processes of learning and memory.

TL;DR: It is shown that self-administration of cocaine, but not passive cocaine infusions, produced a persistent potentiation of VTA excitatory synapses, which was still present after 3 months abstinence and was evident even after 3 weeks of extinction training.

TL;DR: It is demonstrated that CB1 receptors are essential for adaptive responses produced by chronic morphine but not by chronic cocaine treatment, and the inability of morphine to induce rewarding effects in the absence of CB1 cannabinoid receptors is demonstrated.

TL;DR: It is shown that operant cocaine self-administration inhibits long-term depression in both structures after 1 d of abstinence, and LTD was abolished exclusively in the nucleus accumbens core of cocaineself-administering rats, suggesting that voluntary cocaineSelf-Administration induced long-lasting neuroadaptations in the core that could underlie drug-seeking behavior and relapse.

TL;DR: The enhanced manifestations of neuropathic pain were replicated in irradiated wild-type mice reconstituted with bone marrow cells from CB2 knock-outs, thus demonstrating the implication of the CB2 receptor expressed in hematopoietic cells in the development of neuropathy pain at the spinal cord.