M
Mirco Fanelli
Researcher at University of Urbino
Publications - 65
Citations - 3668
Mirco Fanelli is an academic researcher from University of Urbino. The author has contributed to research in topics: Acute promyelocytic leukemia & Epigenetics. The author has an hindex of 25, co-authored 59 publications receiving 3364 citations. Previous affiliations of Mirco Fanelli include European Institute of Oncology & University of Camerino.
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Brønsted Acid Catalyzed Bisindolization of α-Amido Acetals: Synthesis and Anticancer Activity of Bis(indolyl)ethanamino Derivatives
Michele Mari,Aurora Tassoni,Simone Lucarini,Mirco Fanelli,Giovanni Piersanti,Gilberto Spadoni +5 more
TL;DR: The marine natural alkaloids 2,2-di(6′-bromo-3′-indolyl)-ethylamine was the most active compound and could be a lead candidate for further optimization and the biological role of this brominated bisindole marine alkaloid is presented.
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Synthesis, Basicity, Structural Characterization, and Biochemical Properties of Two [(3-Hydroxy-4-pyron-2-yl)methyl]amine Derivatives Showing Antineoplastic Features.
Stefano Amatori,Gianluca Ambrosi,Mirco Fanelli,Mauro Formica,Vieri Fusi,Luca Giorgi,Eleonora Macedi,Mauro Micheloni,Paola Paoli,Roberto Pontellini,Patrizia Rossi +10 more
TL;DR: Solid-state results and MD simulations in water show that malten, because of its molecular topology, should be more prone than maltonis to act as a donor of H-bonds in intermolecular contacts, thus it should give a better noncovalent approach with the negatively charged DNA.
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Premature senescence induced by DNA demethylating agent (Decitabine) as therapeutic option for malignant pleural mesothelioma.
TL;DR: The introduction of Decitabine in therapy for malignant pleural mesothelioma was analyzed observing that, despite the ability to induce profound biological effects in MPM cells, the drug failed to generate a massive apoptotic response.
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Real-time quantitative PCR array to study drug-induced changes of gene expression in tumor cell lines
TL;DR: A RT-qPCR array that exploits SYBR Green dyebased detection to perform reliable gene expression analysis on 41 genes involved in several pathways linked to DNA damage response, cell cycle progression, cellular senescence, and programmed cell death is described.
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Dissecting Molecular Features of Gliomas: Genetic Loci and Validated Biomarkers.
Antonietta Arcella,Fiona Limanaqi,Rosangela Ferese,Francesca Biagioni,Maria Antonietta Oliva,Marianna Storto,Mirco Fanelli,Stefano Gambardella,Francesco Fornai +8 more
TL;DR: This review summarizes available molecular features that represent solid tools for the genetic diagnosis of gliomas at present or in the next future.