M
Mireia Duñach
Researcher at Autonomous University of Barcelona
Publications - 60
Citations - 4103
Mireia Duñach is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Phosphorylation & Wnt signaling pathway. The author has an hindex of 31, co-authored 59 publications receiving 3859 citations. Previous affiliations of Mireia Duñach include Boston University.
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Journal ArticleDOI
Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation
Santiago Roura,Susana Miravet,Jose Piedra,Jose Piedra,Antonio García de Herreros,Mireia Duñach +5 more
TL;DR: Transient transfections of different mutants demonstrated that Tyr-654 is phosphorylated in conditions in which adherens junctions are disrupted and evidenced that binding ofβ-catenin to E-cadherin in vivo is controlled by phosphorylation of β- catenin Tyr-652.
Journal ArticleDOI
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.
Verónica Rodilla,Alberto Villanueva,Antonia Obrador-Hevia,Àlex Robert-Moreno,Vanessa Fernández-Majada,Andrea Grilli,Nuria Lopez-Bigas,Nicolás Bellora,M. Mar Albà,Ferran Torres,Mireia Duñach,Xavier Sanjuan,Sara González,Thomas Gridley,Gabriel Capellá,Anna Bigas,Lluis Espinosa +16 more
TL;DR: Notch activation, accomplished by β-catenin-mediated up-regulation of Jagged1, is required for tumorigenesis in the intestine, and this mechanism is operating in human tumors from Familial Adenomatous Polyposis patients.
Journal ArticleDOI
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate β-catenin Tyr-142 phosphorylation and β-catenin-α-catenin interaction
Jose Piedra,Jose Piedra,Susana Miravet,Julio Castaño,Hector G. Palmer,Nora Heisterkamp,Antonio García de Herreros,Mireia Duñach +7 more
TL;DR: Results indicate that p120 catenin acts as a docking protein facilitating the activation of Fer/Fyn tyrosine kinases by Yes and demonstrate the role of these p 120 caten in-associated kinases in the regulation of β-catenin-α-catanin interaction.
Journal ArticleDOI
Regulation of β-catenin structure and activity by tyrosine phosphorylation.
Jose Piedra,Daniel Martínez,Julio Castaño,Susana Miravet,Mireia Duñach,Antonio García de Herreros +5 more
TL;DR: The results explain how phosphorylation of beta-catenin in Tyr-654 modifies the tertiary structure of this protein and the interaction with its different partners.
Journal ArticleDOI
Bcr-Abl stabilizes β-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
Addolorata Coluccia,Addolorata Coluccia,Angelo Vacca,Mireia Duñach,Luca Mologni,Sara Redaelli,Victor H. Bustos,Daniela Benati,Lorenzo A. Pinna,Carlo Gambacorti-Passerini,Carlo Gambacorti-Passerini +10 more
TL;DR: It is shown that Bcr‐Abl levels control the degree of β‐catenin protein stabilization by affecting its Y/S/T‐phospho content in CML cells.