M
Mireille Sebbag
Researcher at University of Toulouse
Publications - 43
Citations - 2869
Mireille Sebbag is an academic researcher from University of Toulouse. The author has contributed to research in topics: Filaggrin & Citrullination. The author has an hindex of 23, co-authored 43 publications receiving 2676 citations. Previous affiliations of Mireille Sebbag include BioMérieux & Paul Sabatier University.
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Peptidyl arginine deiminase type 2 (PAD‐2) and PAD‐4 but not PAD‐1, PAD‐3, and PAD‐6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation
Céline Foulquier,Mireille Sebbag,Cyril Clavel,Sabine Chapuy-Regaud,Roula Al Badine,Marie-Claire Méchin,Christian Vincent,Rachida Nachat,Michiyuki Yamada,Hidenari Takahara,Michel Simon,Marina Guerrin,Guy Serre +12 more
TL;DR: PAD-2 and PAD-4 are the only PAD isotypes expressed in the synovial tissue of patients with RA and those with other arthritides, and both enzymes were demonstrable within or in the vicinity of citrullinated fibrin deposits.
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The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies.
Mireille Sebbag,Michel Simon,Christian Vincent,C Masson-Bessière,E Girbal,Jean-Jacques Durieux,Guy Serre +6 more
TL;DR: Results indicate that AKA and APF are largely the same autoantibodies that recognize human epidermal filaggrin and (pro) filag Grin-related proteins of buccal epithelial cells.
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Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen
Cyril Clavel,Leonor Nogueira,Laetitia Laurent,Cristina Iobagiu,Christian Vincent,Mireille Sebbag,Guy Serre +6 more
TL;DR: An in vitro human model demonstrates the inflammatory potential of ACPA-containing ICs via engagement of FcgammaRIIa at the surface of macrophages, strongly supporting their pathophysiologic involvement.
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Cytokine stimulation of t lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha , but not interleukin-10 : possible relevance to pathophysiology of rheumatoid arthritis
TL;DR: The results from this model of cognate interaction suggest that cytokine‐stimulated T cells, interacting with macrophages in the rheumatoid synovial membrane, may contribute to the continuous excessive production of TNF‐α observed in the RA joint, and to the imbalance of pro‐ inflammatory cytokines over anti‐inflammatory cytokines.
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Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: Relevance to antifilaggrin autoantibodies
Dominique Baeten,I Peene,Ann Union,Lydie Meheus,Mireille Sebbag,Guy Serre,Eric Veys,Filip De Keyser +7 more
TL;DR: In this article, the presence of citrullinated proteins in the synovial membrane of patients with rheumatoid arthritis (RA) and controls, and a possible relationship with antifilaggrin autoantibody (AFA) reactivity was investigated by double immunofluorescence on frozen sections.