L
Leonor Nogueira
Researcher at University of Toulouse
Publications - 47
Citations - 2845
Leonor Nogueira is an academic researcher from University of Toulouse. The author has contributed to research in topics: Epitope & Autoantibody. The author has an hindex of 23, co-authored 47 publications receiving 2681 citations. Previous affiliations of Leonor Nogueira include French Institute of Health and Medical Research & Paul Sabatier University.
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Journal ArticleDOI
The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin.
C Masson-Bessière,Mireille Sebbag,Elisabeth Girbal-Neuhauser,Leonor Nogueira,Christian Vincent,Tatsuo Senshu,Guy Serre +6 more
TL;DR: Results show that deiminated forms of fibrin deposited in the rheumatoid synovial membranes are the major target of AFA, and suggest that autoimmunization against deimination fibrIn is a critical step in RA pathogenesis.
Journal ArticleDOI
Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen
Cyril Clavel,Leonor Nogueira,Laetitia Laurent,Cristina Iobagiu,Christian Vincent,Mireille Sebbag,Guy Serre +6 more
TL;DR: An in vitro human model demonstrates the inflammatory potential of ACPA-containing ICs via engagement of FcgammaRIIa at the surface of macrophages, strongly supporting their pathophysiologic involvement.
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In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum.
C Masson-Bessière,Mireille Sebbag,Jean-Jacques Durieux,Leonor Nogueira,Christian Vincent,Elisabeth Girbal-Neuhauser,R. Durroux,Alain Cantagrel,Guy Serre +8 more
TL;DR: AFA‐secreting plasma cells are present in the synovial tissue of RA patients and AFA can represent a significant proportion of the IgG secreted within the rheumatoid pannus.
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Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins
Mireille Sebbag,Nathalie Moinard,Isabelle Auger,Cyril Clavel,Jacques Arnaud,Leonor Nogueira,Jean Roudier,Guy Serre +7 more
TL;DR: The immunological conflict between ACPA and fibrin could sustain synovial inflammation not only via pro‐inflammatory effector mechanisms but also via impairment of fibrinolysis.
Journal ArticleDOI
Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrinogen
Isabelle Auger,Mireille Sebbag,Christian Vincent,Nathalie Balandraud,Sandrine Guis,Leonor Nogueira,Björn Svensson,Alain Cantagrel,Guy Serre,Jean Roudier +9 more
TL;DR: The RA-associated HLA–DRB1*0404 allele is also associated with production of antibodies to citrullinated fibrinogen, and T cell proliferation in response to citrillinated or uncitrullination fibr inogen peptides is frequent in RA patients and very infrequent in controls.