Mirella Ghirardi

TL;DR: Through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage.

TL;DR: The results suggest that whereas activation of PKA is sufficient to trigger the facilitation of nondepressed synapses, activation of both PKA and PKC is required to facilitate depressedsynapses, with the contribution of PKC becoming progressively more important as synaptic transmission becomes more depressed.

TL;DR: An in vitro model of soma-to-soma paired Helix B2 neurons, that establishes bidirectional excitatory synapses, found that the formation and activity-dependent short-term plasticity of these synapses is dependent on the MAPK/Erk pathway, indicating that some of the multiple extranuclear functions of MAPK /Erk in neurons can be mediated by the same multifunctional presynaptic target.

TL;DR: The effects of the ablation of the cerebellar vermal area corresponding to lobules VI – VIII and of the flocculus – paraflocculus of both sides on the spontaneous eye movements performed in the light and in the dark in head‐restrained pigmented rats have been studied.

TL;DR: The microelectrode array technology and the optimization of the coupling between neurons and microtransducers to detect subthreshold synaptic signals are reviewed, and MEA studies of circuit formation and activity in invertebrate models such as Lymnaea, Aplysia, and Helix are reported.