Mirko Scheibinger

TL;DR: The single-cell proteomes enabled the de novo reconstruction of a developmental trajectory using protein expression levels, revealing proteins that greatly increased in expression during differentiation of hair cells and those that decreased during differentiation.

TL;DR: In this article, the authors purify different cochlear cell types from neonatal mice, validate the composition of the different groups with single-cell RNA sequencing (RNA-seq), and assess the various groups' potential to grow into inner ear organoids.

TL;DR: Differential trail analysis revealed high-resolution dynamics of transcripts that control striolar and extrastriolar bundle development, including those that encode proteins that regulate [Ca2+]i or mediate crosslinking and lengthening of actin filaments.

TL;DR: It is concluded that a single ototoxic drug application provides an experimental framework to study the precise onset and timing of utricle hair cell regeneration in vivo and indicates that initial triggers and signaling events occur already within a few hours after aminoglycoside exposure.

TL;DR: In this paper, the authors presented a validated single-cell RNA sequencing resource of the avian cochlea, including specific markers for three distinct types of sensory hair cells, including a previously unknown subgroup, which they called superior tall hair cells.