M
Mitchell B. Schaffler
Researcher at City College of New York
Publications - 146
Citations - 18590
Mitchell B. Schaffler is an academic researcher from City College of New York. The author has contributed to research in topics: Osteocyte & Bone remodeling. The author has an hindex of 70, co-authored 143 publications receiving 17173 citations. Previous affiliations of Mitchell B. Schaffler include Icahn School of Medicine at Mount Sinai & Ford Motor Company.
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Journal ArticleDOI
Rotator-cuff changes in asymptomatic adults. The effect of age, hand dominance and gender
TL;DR: The results indicate that rotator-cuff lesions are a natural correlate of ageing, and are often present with no clinical symptoms, and should be treated based on clinical findings and not on the results of imaging.
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Bone remodeling in response to in vivo fatigue microdamage
TL;DR: Data from two experiments support the hypothesis that fatigue microdamage is a significant factor in the initiation of intracortical bone remodeling.
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Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo.
TL;DR: The studies show that osteocyte apoptosis is induced by bone fatigue, this apoptotic activity is localized to regions of bone that contain microcracks, and osteoclastic resorption after fatigue also coincides with regions of osteocytes apoptosis.
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Bone Microdamage and Skeletal Fragility in Osteoporotic and Stress Fractures
David B. Burr,Mark R. Forwood,David P. Fyhrie,R. Bruce Martin,Mitchell B. Schaffler,Charles H. Turner +5 more
TL;DR: It is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.
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FSH Directly Regulates Bone Mass
Li Sun,Yuanzhen Peng,Allison C. Sharrow,Allison C. Sharrow,Jameel Iqbal,Zhiyuan Zhang,Dionysios J. Papachristou,Dionysios J. Papachristou,Samir Zaidi,Ling-Ling Zhu,Beatrice B. Yaroslavskiy,Beatrice B. Yaroslavskiy,Hang Zhou,Alberta Zallone,M. Ram Sairam,T. Rajendra Kumar,Wei Bo,Jonathan Braun,Luis Cardoso-Landa,Mitchell B. Schaffler,Baljit S. Moonga,Harry C. Blair,Harry C. Blair,Mone Zaidi +23 more
TL;DR: It is suggested that high circulating FSH causes hypogonadal bone loss and that Osteoclasts and their precursors possess G(i2alpha)-coupled FSHRs that activate MEK/Erk, NF-kappaB, and Akt to result in enhanced osteoclast formation and function.