L
Li Sun
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 144
Citations - 7172
Li Sun is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Osteoclast & Osteoporosis. The author has an hindex of 40, co-authored 137 publications receiving 6055 citations. Previous affiliations of Li Sun include Mount Sinai Hospital & Drexel University.
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Journal ArticleDOI
FSH Directly Regulates Bone Mass
Li Sun,Yuanzhen Peng,Allison C. Sharrow,Allison C. Sharrow,Jameel Iqbal,Zhiyuan Zhang,Dionysios J. Papachristou,Dionysios J. Papachristou,Samir Zaidi,Ling-Ling Zhu,Beatrice B. Yaroslavskiy,Beatrice B. Yaroslavskiy,Hang Zhou,Alberta Zallone,M. Ram Sairam,T. Rajendra Kumar,Wei Bo,Jonathan Braun,Luis Cardoso-Landa,Mitchell B. Schaffler,Baljit S. Moonga,Harry C. Blair,Harry C. Blair,Mone Zaidi +23 more
TL;DR: It is suggested that high circulating FSH causes hypogonadal bone loss and that Osteoclasts and their precursors possess G(i2alpha)-coupled FSHRs that activate MEK/Erk, NF-kappaB, and Akt to result in enhanced osteoclast formation and function.
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The myokine irisin increases cortical bone mass
Graziana Colaianni,Concetta Cuscito,Teresa Mongelli,Paolo Pignataro,Cinzia Buccoliero,Peng Liu,Ping Lu,Loris Sartini,Mariasevera Di Comite,Giorgio Mori,Adriana Di Benedetto,Giacomina Brunetti,Tony Yuen,Li Sun,Janne E. Reseland,Silvia Colucci,Maria I. New,Mone Zaidi,Saverio Cinti,Maria Grano +19 more
TL;DR: It is shown that a molecule irisin derived from skeletal muscle in response to exercise has profound effects in enhancing mass and improving the geometry and strength specifically of cortical bone, the key function of which is to resist bending and torsion.
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Genotype–phenotype correlation in 1,507 families with congenital adrenal hyperplasia owing to 21-hydroxylase deficiency
Maria I. New,Moolamannil Abraham,Brian Gonzalez,Miroslav Dumić,Maryam Razzaghy-Azar,David Chitayat,Li Sun,Mone Zaidi,Robert C. Wilson,Tony Yuen +9 more
TL;DR: By identifying the predominant phenotype for a given genotype, these findings should assist physicians in prenatal diagnosis and genetic counseling of parents who are at risk for having a child with CAH.
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Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma
Maria I. New,Yu K. Tong,Tony Yuen,Peiyong Jiang,Christian Pina,K.C. Allen Chan,Ahmed Khattab,Gary J. W. Liao,Mabel Yau,Se-Min Kim,Rossa W.K. Chiu,Li Sun,Mone Zaidi,Y.M. Dennis Lo +13 more
TL;DR: The fetal CAH status was correctly deduced by targeted MPS of DNA in maternal plasma, as early as 5 weeks 6 days of gestation, representing a generic approach for noninvasive prenatal testing for an array of autosomal recessive disorders.
Journal ArticleDOI
Oxytocin is an anabolic bone hormone
Roberto Tamma,Graziana Colaianni,Ling Ling Zhu,Adriana DiBenedetto,Giovanni Greco,Gabriella Montemurro,Nicola Patano,Maurizio Strippoli,R. Vergari,Lucia Mancini,Silvia Colucci,Maria Grano,Roberta Faccio,Xuan Liu,Jianhua Li,Sabah Usmani,Marilyn Bachar,Itai Bab,Katsuhiko Nishimori,Larry J. Young,Christoph Buettner,Jameel Iqbal,Li Sun,Mone Zaidi,Alberta Zallone +24 more
TL;DR: Together, the complementary genetic and pharmacologic approaches reveal OT as a novel anabolic regulator of bone mass, with potential implications for osteoporosis therapy.