Mitsugu Hironaka

TL;DR: The results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis.

TL;DR: The mutations and/or preferential expression of GNNK‐ isoform of the c‐kit gene might play an important role in the development of testicular GCTs, and these tumors may also be targets for STI571, which is a promising drug for advanced and metastatic GISTs.

TL;DR: This study evaluated mutations in exon 9 and exon 13 of the c‐kit gene by both polymerase chain reaction‐single strand conformation polymorphism analysis and direct sequencing in 48 GISTs in a Japanese population, for which the clinicopatho‐logical and immunohistochemical features and mutations inExon 11 had previously been reported.

TL;DR: The quantitative predominance of squamous metaplasia in the honeycombed areas may not be a precursor for lung carcinoma, but might reflect a constitutional susceptibility of UIP patients to develop a lung carcinomas.

TL;DR: The data suggest that the monoclonal expansion precedes K-ras mutation in cystic tumors of the pancreas from female patients, and that both IPMT and MCT seem to arise from polyclonal epithelia and to be replaced by monOClonal neoplastic cells as they undergo dysplastic changes and K-ra mutation.