H
Hirokazu Taniguchi
Researcher at Nagasaki University
Publications - 329
Citations - 7634
Hirokazu Taniguchi is an academic researcher from Nagasaki University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 40, co-authored 296 publications receiving 6181 citations. Previous affiliations of Hirokazu Taniguchi include Kanazawa University.
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Journal ArticleDOI
Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer.
Toshiaki Hirasawa,Takuji Gotoda,Satoshi Miyata,You Kato,Tadakazu Shimoda,Hirokazu Taniguchi,Junko Fujisaki,Takeshi Sano,Toshiharu Yamaguchi +8 more
TL;DR: UD-type intramucosal EGC 20 mm or less in size without lymphatic-vascular capillary involvement and ulcerative findings presents a negligible risk of lymph node metastasis, and it is proposed that in this circumstance ER could be considered.
Journal Article
Global Gene Expression Analysis of Gastric Cancer by Oligonucleotide Microarrays
Yoshitaka Hippo,Hirokazu Taniguchi,Shuichi Tsutsumi,Naoko Machida,Ja-Mun Chong,Masashi Fukayama,Tatsuhiko Kodama,Hiroyuki Aburatani +7 more
TL;DR: A two-way clustering algorithm successfully distinguished cancer tissues from noncancerous tissues and several genes associated with lymph node metastasis including Oct-2 or histological types including Liver-Intestine Cadherin were identified.
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Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas
Shinichi Fukumoto,Naoko Yamauchi,Hisashi Moriguchi,Yoshitaka Hippo,Akira Watanabe,Junji Shibahara,Hirokazu Taniguchi,Shumpei Ishikawa,Hirotaka Ito,Shogo Yamamoto,Hiroko Iwanari,Mitsugu Hironaka,Yuichi Ishikawa,Toshiro Niki,Yasunori Sohara,Tatsuhiko Kodama,Masaharu Nishimura,Masashi Fukayama,Hirotoshi Dosaka-Akita,Hiroyuki Aburatani +19 more
TL;DR: The results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis.
Journal Article
Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes.
Yoshitaka Hippo,Masakazu Yashiro,Masami Ishii,Hirokazu Taniguchi,Shuichi Tsutsumi,Kosei Hirakawa,Tatsuhiko Kodama,Hiroyuki Aburatani +7 more
TL;DR: This study performs global analysis on differential gene expression of a scirrhous gastric cancer cell line and its derivative sublines with high potential for metastasis to the peritoneal cavity and lymph nodes in a nude mice model and reveals two functional gene clusters with altered expression.
Journal ArticleDOI
AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells.
Hirokazu Taniguchi,Tadaaki Yamada,Tadaaki Yamada,Rong Wang,Keiko Tanimura,Yuta Adachi,Akihiro Nishiyama,Azusa Tanimoto,Shinji Takeuchi,Luiz H. Araujo,Mariana Boroni,Akihiro Yoshimura,Shinsuke Shiotsu,Isao Matsumoto,Satoshi Watanabe,Toshiaki Kikuchi,Satoru Miura,Hiroshi Tanaka,Takeshi Kitazaki,Hiroyuki Yamaguchi,Hiroshi Mukae,Junji Uchino,Hisanori Uehara,Koichi Takayama,Seiji Yano +24 more
TL;DR: It is shown that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimERTinib and proposed the combination of Osimert inib with AXL inhibitor as a potential therapeutic approach in such resistant cancers.