H
Hirotaka Ito
Researcher at Brigham and Women's Hospital
Publications - 61
Citations - 1582
Hirotaka Ito is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 46 publications receiving 1193 citations. Previous affiliations of Hirotaka Ito include University of Tokyo.
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Journal ArticleDOI
Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.
Yingqiu Guo,Yongxin Chen,Hirotaka Ito,Akira Watanabe,Xijin Ge,Tatsuhiko Kodama,Hiroyuki Aburatani +6 more
TL;DR: The cloning and characterization of a novel gene, lin-28 homolog B (LIN28B), which is overexpression in hepatocellular carcinoma, and its findings strongly implicate a critical role of LIN28B during development and tumorigenesis and suggest a possible novel mechanism.
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Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas
Shinichi Fukumoto,Naoko Yamauchi,Hisashi Moriguchi,Yoshitaka Hippo,Akira Watanabe,Junji Shibahara,Hirokazu Taniguchi,Shumpei Ishikawa,Hirotaka Ito,Shogo Yamamoto,Hiroko Iwanari,Mitsugu Hironaka,Yuichi Ishikawa,Toshiro Niki,Yasunori Sohara,Tatsuhiko Kodama,Masaharu Nishimura,Masashi Fukayama,Hirotoshi Dosaka-Akita,Hiroyuki Aburatani +19 more
TL;DR: The results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis.
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Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.
Hirotaka Ito,Shin-Ichi Funahashi,Naoko Yamauchi,Junji Shibahara,Yutaka Midorikawa,Shigeto Kawai,Yasuko Kinoshita,Akira Watanabe,Yoshitaka Hippo,Toshihiko Ohtomo,Hiroko Iwanari,Atsushi Nakajima,Masatoshi Makuuchi,Masashi Fukayama,Yuichi Hirata,Takao Hamakubo,Tatsuhiko Kodama,Masayuki Tsuchiya,Hiroyuki Aburatani +18 more
TL;DR: This is the first report that ROBO1 is overexpressed in hepatocellular carcinoma and shed into serum in humans, and suggest that RO BO1 is a potential new serologic marker for liver cancer and may represent a new therapeutic target.
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Arming an oncolytic herpes simplex virus Type 1 with a single chain fragment variable antibody against PD-1 for experimental glioblastoma therapy.
Carmela Passaro,Quazim A. Alayo,Isabel DeLaura,John McNulty,Korneel Grauwet,Hirotaka Ito,Vivek Bhaskaran,Marco Mineo,Sean E. Lawler,Khalid Shah,Maria C. Speranza,Maria C. Speranza,William F. Goins,Eric McLaughlin,Soledad Fernandez,David A. Reardon,Gordon J. Freeman,E. Antonio Chiocca,Hiroshi Nakashima +18 more
TL;DR: In situ NG34scFvPD-1 treatment improved the survival with a tail of durable survivorship in 2 syngeneic immunocompetent mouse models of GBM with evidence for antitumor memory.
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Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial
Tomoki Todo,Hirotaka Ito,Yasushi Ino,Hiroshi Ohtsu,Yasunori Ota,Junji Shibahara,Minoru Tanaka +6 more
TL;DR: In this paper , the authors evaluated the efficacy of G47∆, a triple-mutated, third-generation oncolytic herpes simplex virus type 1, in 19 adult patients with residual or recurrent, supratentorial glioblastoma after radiation therapy and temozolomide (UMIN-CTR Clinical Trial Registry UMIN000015995).