M
Mitsuru Futakuchi
Researcher at Nagasaki University
Publications - 122
Citations - 3809
Mitsuru Futakuchi is an academic researcher from Nagasaki University. The author has contributed to research in topics: Bone metastasis & Metastasis. The author has an hindex of 32, co-authored 113 publications receiving 3473 citations. Previous affiliations of Mitsuru Futakuchi include Nagoya City University & University of Nebraska–Lincoln.
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Journal Article
The prostate: A target for carcinogenicity of 2-amino-1 -methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods
Tomoyuki Shirai,Masashi Sano,Seiko Tamano,Satoru Takahashi,Masao Hirose,Mitsuru Futakuchi,Ryohei Hasegawa,Katsumi Imaida,Ken-ichiro Matsumoto,Keiji Wakabayashi,Takashi Sugimura,Nobuyuki Ito +11 more
TL;DR: Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologically evaluated and found to contain prostate carcinomas.
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Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
Kyoko Hashimoto,Hiroki Ochi,Satoko Sunamura,Nobuyoshi Kosaka,Yo Mabuchi,Toru Fukuda,Kenta Yao,Hiroaki Kanda,Keisuke Ae,Atsushi Okawa,Chihiro Akazawa,Takahiro Ochiya,Mitsuru Futakuchi,Shu Takeda,Shingo Sato +14 more
TL;DR: Hsa-miR-940, which was highly secreted by prostate cancer cells, promoted osteogenic differentiation of human mesenchymal stem cells in vitro, and induced extensive osteoblastic lesions in the bone metastatic microenvironment in vivo.
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Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice
TL;DR: Findings were in favor of the widely proposed mode of action of fiber carcinogenesis, that is, frustrated phagocytosis where the mesotheliomagenic microenvironment on the peritoneal surface is neither qualitatively altered by the density of the fibers per area nor by the formation of granulomas against agglomerates.
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Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[a]anthracene
TL;DR: Results indicate that antioxidants, and GTC in particular, inhibit rat mammary gland carcinogenesis after DMBA initiation, and the average size of palpable mammary tumors was significantly smaller in the catechol, phytic acid and catechins groups.
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Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor–Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface
Kalyan C. Nannuru,Mitsuru Futakuchi,Michelle L. Varney,Thomas M. Vincent,Eric G. Marcusson,Rakesh Singh +5 more
TL;DR: It is hypothesized that tumor-stromal interaction alters gene expression in malignant tumor cells and stromal cells creating a unique expression signature that promotes osteolytic breast cancer bone metastasis and that inhibition of such interactions can be developed as targeted therapeutics.