Mkael Symmonds

TL;DR: Using dynamic causal modeling, this study found that drug-induced differences in PE responses could be explained by gain modulation in supragranular pyramidal cells in primary sensory cortex, suggesting that ACh adaptively enhances sensory precision by boosting bottom-up signaling when stimuli are predictable, enabling the brain to respond optimally under different levels of environmental uncertainty.

TL;DR: Dopamine agonists enhance sensitivity to risk in patients with impulse control disorder possibly by impairing risk evaluation in the striatum, providing a potential explanation of why dopamine agonists may lead to an unconscious bias towards risk in susceptible individuals.

TL;DR: The results provide a proof-of-principle demonstration of a novel framework for inferring, noninvasively, neuromodulatory influences on ion channel signaling via specific ionotropic receptors, providing a window on the hidden synaptic events mediating discrete psychological processes in humans.

TL;DR: The findings suggest that the lifetime accrual of sensory experience optimizes functional brain architectures to enable efficient and generalizable predictions of the world.

TL;DR: This work provides evidence that individuals’ choice behaviour is sensitive to both dispersion and asymmetry of outcomes, and shows that a behavioural sensitivity to variance and skewness is mirrored in neuroanatomically dissociable representations of these quantities.