Mo Jiang

TL;DR: The slug-flow crystallizer as mentioned in this paper is a continuous crystallizer with the potential to provide improved control of crystal properties, improved process reproducibility, and reduced scale-up risk.

TL;DR: In this article, an indirect ultrasonication-assisted nucleation process is designed to vary the seed generation rate during operation independent of mass flow rate, by varying the ultrasonization power.

TL;DR: In this article, a review describes recent advances in research on lab-scale solution-based continuous crystallization, including (1) a 5-step general design procedure; (2) key design/operational parameters; (3) process intensification strategies; and (4) case study.

TL;DR: Challenges and opportunities are described for microscale technologies for high-speed continuous processing, plug-and-play modular unit operations with integrated monitoring and control systems, dynamic modeling of unit operations and entire biopharmaceutical manufacturing plants to support process development and plant-wide control, and model-based control technologies for optimizing startup, changeover, and shutdown.

TL;DR: In this article, the growth and dissolution kinetics of monosodium glutamate crystals of varying shapes were monitored using in-process attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), focused beam reflectance measurement (FBRM), particle vision and measurement (PVM), and off-line optical microscopy.