C
Charles D. Papageorgiou
Researcher at Takeda Pharmaceutical Company
Publications - 18
Citations - 415
Charles D. Papageorgiou is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Crystallization & Heat transfer. The author has an hindex of 8, co-authored 18 publications receiving 288 citations. Previous affiliations of Charles D. Papageorgiou include Millennium Pharmaceuticals.
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Journal ArticleDOI
Continuous-Flow Tubular Crystallization in Slugs Spontaneously Induced by Hydrodynamics
Mo Jiang,Zhilong Zhu,Ernesto Jimenez,Charles D. Papageorgiou,Josh Waetzig,Andrew Hardy,Marianne Langston,Richard D. Braatz,Richard D. Braatz +8 more
TL;DR: The slug-flow crystallizer as mentioned in this paper is a continuous crystallizer with the potential to provide improved control of crystal properties, improved process reproducibility, and reduced scale-up risk.
Journal ArticleDOI
Indirect Ultrasonication in Continuous Slug-Flow Crystallization
Mo Jiang,Charles D. Papageorgiou,Josh Waetzig,Andrew Hardy,Marianne Langston,Richard D. Braatz +5 more
TL;DR: In this article, an indirect ultrasonication-assisted nucleation process is designed to vary the seed generation rate during operation independent of mass flow rate, by varying the ultrasonization power.
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The Pharmaceutical Drying Unit Operation: An Industry Perspective on Advancing the Science and Development Approach for Scale-Up and Technology Transfer
Edward W. Conder,Andrew Cosbie,John Gaertner,William Hicks,Seth Huggins,Claire S. MacLeod,Brenda Remy,Bing-Shiou Yang,Joshua Engstrom,David J. Lamberto,Charles D. Papageorgiou +10 more
TL;DR: In this paper, the authors survey current practices within the industry for drying development related to chemical and physical stability, drying kinetics, and powder properties and highlight common development gaps for improving drying development workflows within the pharmaceutical industry.
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Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material
TL;DR: A flow chemistry process for the synthesis of a key boronic acid starting material was developed utilizing flow flash chemistry that allowed formation and subsequent productive reaction of an unstable organolithium intermediate.
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Application of model-free and model-based Quality-by-Control (QbC) for the efficient design of pharmaceutical crystallization processes
TL;DR: The design of pharmaceutical crystallization processes is a challenging engineering problem because of the specific and versatile quality requirements of the end-product, amplified by the tight regulatory requirements.