M
Mohamed Makrelouf
Researcher at French Institute of Health and Medical Research
Publications - 26
Citations - 696
Mohamed Makrelouf is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 16 publications receiving 617 citations.
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Journal ArticleDOI
A predominantly neolithic origin for Y-chromosomal DNA variation in North Africa
Barbara Arredi,Barbara Arredi,Barbara Arredi,Estella S. Poloni,Silvia Paracchini,Tatiana Zerjal,Dahmani M. Fathallah,Mohamed Makrelouf,Vincenzo Lorenzo Pascali,Andrea Novelletto,Chris Tyler-Smith,Chris Tyler-Smith +11 more
TL;DR: The Neolithic transition in this part of the world was accompanied by demic diffusion of Afro-Asiatic-speaking pastoralists from the Middle East, and it is suggested that the North African pattern of Y-chromosomal variation is largely of Neolithic origin.
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Mutations in COL6A3 Cause Severe and Mild Phenotypes of Ullrich Congenital Muscular Dystrophy
Ercan Demir,Patrizia Sabatelli,Valérie Allamand,Ana Ferreiro,Behzad Moghadaszadeh,Mohamed Makrelouf,Haluk Topaloglu,Bernard Echenne,Luciano Merlini,Pascale Guicheney +9 more
TL;DR: Mutations in COL6A3 are described in UCMD for the first time and illustrate the wide spectrum of phenotypes which can be caused by collagen VI deficiency.
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IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients.
Mourad Belkhelfa,Hayet Rafa,Oussama Medjeber,Amina Arroul-Lammali,Nassima Behairi,Myriam Abada-Bendib,Mohamed Makrelouf,Soreya Belarbi,Ahmed Nacer Masmoudi,Meriem Tazir,Chafia Touil-Boukoffa +10 more
TL;DR: The data indicate that the proinflammatory cytokine production seems, in part, to be involved in neurological deleterious effects observed during the development of AD through NO pathway.
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IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases
Marie Tauber,Elodie Bal,Xue-Yuan Pei,Marine Madrange,Amel Khelil,Houria Sahel,Akila Zenati,Mohamed Makrelouf,Khaled Boubridaa,Amel Chiali,Naima Smahi,Farida Otsmane,Bakar Bouajar,Slaheddine Marrakchi,Hamida Turki,Emmanuelle Bourrat,Manuelle Viguier,Yamina Hamel,Hervé Bachelez,Asma Smahi +19 more
TL;DR: Null mutations were associated with severe clinical phenotypes, whereas hypomorphic mutations were identified in both localized (palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau) and generalized variants.
Journal ArticleDOI
The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells
Elise Pepermans,Elise Pepermans,Elise Pepermans,Vincent Michel,Vincent Michel,Vincent Michel,Richard J. Goodyear,Crystel Bonnet,Crystel Bonnet,Crystel Bonnet,Samia Abdi,Typhaine Dupont,Typhaine Dupont,Typhaine Dupont,Souad Gherbi,Muriel Holder,Mohamed Makrelouf,Jean-Pierre Hardelin,Jean-Pierre Hardelin,Jean-Pierre Hardelin,Sandrine Marlin,Akila Zenati,Guy P. Richardson,Paul Avan,Paul Avan,Amel Bahloul,Amel Bahloul,Amel Bahloul,Christine Petit +28 more
TL;DR: It is shown that Pcdh15‐CD2 is an essential component of tip‐links in mature auditory hair cells, and this will also serve as a basis for the development of gene therapy for deafness caused by PCDH15 defects in humans.