M
Mohammad Akhter Hossain
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 9
Citations - 226
Mohammad Akhter Hossain is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Relaxin-3 & Neuropeptide. The author has an hindex of 6, co-authored 9 publications receiving 166 citations. Previous affiliations of Mohammad Akhter Hossain include University of Melbourne.
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Journal ArticleDOI
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
Fazel Shabanpoor,Mohammad Akhter Hossain,Philip Ryan,Alessia Belgi,Sharon Layfield,Martina Kocan,Suode Zhang,Chrishan S. Samuel,Andrew L. Gundlach,Ross A. D. Bathgate,Frances Separovic,John D. Wade +11 more
TL;DR: These novel RXFP3-selective peptides represent valuable pharmacological tools to study the physiological roles of H3 relaxin/RXFP3 systems in the brain and important leads for the development of novel compounds for the treatment of affective and cognitive disorders.
Journal ArticleDOI
Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice
Craig M. Smith,Craig M. Smith,Berenice E. Chua,Cary Zhang,Cary Zhang,Andrew W. Walker,Andrew W. Walker,Mouna Haidar,Mouna Haidar,David Hawkes,Fazel Shabanpoor,Mohammad Akhter Hossain,Mohammad Akhter Hossain,John D. Wade,John D. Wade,K. Johan Rosengren,Andrew L. Gundlach,Andrew L. Gundlach +17 more
TL;DR: Existing anatomical and functional evidence suggests the highly-conserved neuropeptide, relaxin-3, which signals via its cognate Gi/o-protein coupled receptor, RXFP3, contributes to behavioural arousal and feeding behaviour in rodents, and in light of the established biological and translational importance of other arousal systems, relax in-3/RXFP3 networks warrant further experimental investigation.
Journal ArticleDOI
Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice
Cary Zhang,Berenice E. Chua,Annie Yang,Fazel Shabanpoor,Mohammad Akhter Hossain,John D. Wade,K. Johan Rosengren,Craig M. Smith,Andrew L. Gundlach,Andrew L. Gundlach +9 more
TL;DR: Overall, data suggest exogenous RXFP3 agonists can reduce elevated (FG-7142-induced) levels of anxiety in mice; data important for gauging how conserved such effects are, with a view to modelling human pathophysiology and the likely therapeutic potential of RX FP3-targeted drugs.
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The emerging role of probiotics as a mitigation strategy against coronavirus disease 2019 (COVID-19).
Rasoul Mirzaei,Adeleh Attar,Saher Papizadeh,Ali Salimi Jeda,Seyed Reza Hosseini-Fard,Elaheh Jamasbi,Sima Kazemi,Saman Amerkani,Gholam Reza Talei,Pouya Moradi,Saba Jalalifar,Rasoul Yousefimashouf,Mohammad Akhter Hossain,Hossein Keyvani,Sajad Karampoor +14 more
TL;DR: In this paper, the effectiveness of various probiotics for preventing virus-induced respiratory infectious diseases, especially those that could be employed for COVID-19 patients, was summarized, and the benefits of probiotics are strain-specific, and it is necessary to identify the bacterial strains that are scientifically established to be beneficial.
Journal ArticleDOI
RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior.
Alan Kania,Alan Kania,Agata Szlaga,Patryk Sambak,Anna Gugula,Ewa Błasiak,Maria Vittoria Micioni Di Bonaventura,Mohammad Akhter Hossain,Carlo Cifani,Grzegorz Hess,Andrew L. Gundlach,Anna Blasiak +11 more
TL;DR: It is demonstrated that relaxin-3/RXFP3 signaling in the hypothalamic paraventricular nucleus (PVN) is necessary for the expression of binge-eating behavior in female rats and identified RXFP3 as a therapeutic target for binge-like eating disorders.