M
Mohammed S. Al-Dosari
Researcher at King Saud University
Publications - 98
Citations - 3239
Mohammed S. Al-Dosari is an academic researcher from King Saud University. The author has contributed to research in topics: Chemistry & HBsAg. The author has an hindex of 24, co-authored 86 publications receiving 2668 citations. Previous affiliations of Mohammed S. Al-Dosari include King Khalid University.
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Journal ArticleDOI
Nonviral gene delivery: principle, limitations, and recent progress.
Mohammed S. Al-Dosari,Xiang Gao +1 more
TL;DR: This review focuses on existing and emerging concepts of chemical and physical methods for delivery of therapeutic nucleic acid molecules in vivo and puts the emphasis on discussion about problems associated with current nonviral methods and recent efforts toward refinement ofnonviral approaches.
Journal ArticleDOI
Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families.
Anas M. Alazami,Nisha Patel,Hanan E. Shamseldin,Shamsa Anazi,Mohammed S. Al-Dosari,Fatema Alzahrani,Hadia Hijazi,Muneera J. Alshammari,Mohammed A. Aldahmesh,Mustafa A. Salih,Eissa Faqeih,Amal Alhashem,Fahad A. Bashiri,Mohammed Al-Owain,Amal Y. Kentab,Sameera Sogaty,Saeed Al Tala,Mohamad-Hani Temsah,Maha Tulbah,Rasha Aljelaify,Saad AlShahwan,Mohammed Zain Seidahmed,Adnan A. Alhadid,Hesham Aldhalaan,Fatema AlQallaf,Wesam Kurdi,Majid Alfadhel,Zainab A. Babay,Mohammad Alsogheer,Namik Kaya,Zuhair N. Al-Hassnan,Ghada M H Abdel-Salam,Nouriya Al-Sannaa,Fuad Al Mutairi,Heba Y. El Khashab,Heba Y. El Khashab,Saeed Bohlega,Xiaofei Jia,Henry C. Nguyen,Rakad Hammami,Nouran Adly,Jawahir Y. Mohamed,Firdous Abdulwahab,Niema Ibrahim,Ewa A. Naim,Banan Al-Younes,Brian F. Meyer,Mais Hashem,Ranad Shaheen,Yong Xiong,Mohamed Abouelhoda,Abdulrahman A. Aldeeri,Dorota Monies,Fowzan S. Alkuraya,Fowzan S. Alkuraya +54 more
TL;DR: This paper performed whole-exome sequencing on 143 multiplex consanguineous families in which known disease genes had been excluded by autozygosity mapping and candidate gene analysis and identified 69 recessive genes not previously associated with disease.
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Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly
Fowzan S. Alkuraya,Xuyu Cai,Xuyu Cai,Carina Emery,Ganeshwaran H. Mochida,Ganeshwaran H. Mochida,Mohammed S. Al-Dosari,Jillian M. Felie,R. Sean Hill,Brenda J. Barry,Jennifer N. Partlow,Generoso G. Gascon,Amal Y. Kentab,Mohammad Jan,Ranad Shaheen,Yuanyi Feng,Christopher A. Walsh,Christopher A. Walsh +17 more
TL;DR: The role of NDE1 in cell-cycle progression probably contributes to the profound neuronal proliferation defects evident in Nde1-null mice and patients with NDE 1 mutations, demonstrating the essential role in human cerebral cortical neurogenesis.
Journal ArticleDOI
Novel CENPJ mutation causes Seckel syndrome
TL;DR: This report establishes for the first time that mutation of CENPJ can lead to Seckel syndrome and calls for further investigation of the role played by other microcephaly related genes in the pathogenesis of PD.
Journal ArticleDOI
Mutation in ADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus
Anas M. Alazami,Hadia Hijazi,Mohammed S. Al-Dosari,Ranad Shaheen,Amal M. Hashem,Mohammed A. Aldahmesh,Jawahir Y. Mohamed,Amal Y. Kentab,Mustafa A. Salih,Ali Awaji,Tariq Masoodi,Fowzan S. Alkuraya,Fowzan S. Alkuraya +12 more
TL;DR: A novel autosomal recessive form of ID with strabismus with a single missense mutation in ADAT3, which is the first human mutation in the t-RNA editing machinery and expands the landscape of pathways involved in the pathogenesis of ID.