M
Mohammed Shakil Akhtar
Researcher at University of Dammam
Publications - 13
Citations - 209
Mohammed Shakil Akhtar is an academic researcher from University of Dammam. The author has contributed to research in topics: Population & Gene. The author has an hindex of 6, co-authored 11 publications receiving 138 citations. Previous affiliations of Mohammed Shakil Akhtar include King Fahd University Hospital.
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Journal ArticleDOI
Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations
Fernando Dominguez,Sofía Cuenca,Zofia T. Bilińska,Rocío Toro,Eric Villard,Roberto Barriales-Villa,Juan Pablo Ochoa,Folkert W. Asselbergs,Arjan Sammani,Maria Franaszczyk,Mohammed Shakil Akhtar,Maria José Coronado-Albi,Diego Rangel-Sousa,José Rodríguez-Palomares,Juan Jiménez-Jáimez,José Manuel García-Pinilla,Tomás Ripoll-Vera,Maria Victoria Mogollón-Jimenez,Ana Fontalba-Romero,Dolores Garcia-Medina,Julián Palomino-Doza,David de Gonzalo-Calvo,Marcos Cicerchia,Joel Salazar-Mendiguchía,Clara Salas,Sabine Pankuweit,Thomas Morris Hey,Jens Mogensen,Paul J.R. Barton,Philippe Charron,Perry M. Elliott,Pablo García-Pavía +31 more
TL;DR: DCM caused by mutations in BAG3 is characterized by high penetrance in carriers >40 years of age and a high risk of progressive heart failure.
Journal ArticleDOI
Spectrum of α-thalassemia mutations in transfusion-dependent β-thalassemia patients from the Eastern Province of Saudi Arabia.
Mohammed Shakil Akhtar,Fuad Qaw,J. Francis Borgio,Waleed H. Albuali,Ahmed Suliman,Zaki Nasserullah,Sana Al-Jarrash,Amein K. Al-Ali +7 more
TL;DR: The high frequency of α- and β-thal in the Eastern Province of Saudi Arabia and their coinheritance, necessitates the inclusion ofα-thal testing in the current pre marital testing program to highlight the risk to the offspring of affected individuals.
Journal ArticleDOI
Mutations in TRIM63 cause an autosomal-recessive form of hypertrophic cardiomyopathy.
Joel Salazar-Mendiguchía,Juan Pablo Ochoa,Julián Palomino-Doza,Fernando Domínguez,Carles Díez-López,Mohammed Shakil Akhtar,Soraya Ramiro-León,María M Clemente,Antonia Pérez-Cejas,María Robledo,Iria Gomez-Diaz,María Luisa Peña-Peña,Vicente Climent,Francisco Salmerón-Martínez,Celestino Hernández,Pablo Elpidio García-Granja,M Victoria Mogollón,Ivonne J. Cárdenas-Reyes,Marcos Cicerchia,Diego García-Giustiniani,Arsonval Lamounier,Belén Gil-Fournier,Felicitas Diaz-Flores,Rafael Salguero,Luis Santomé,Petros Syrris,Montse Olivé,Pablo García-Pavía,Martin Ortiz-Genga,Perry M. Elliott,Lorenzo Monserrat +30 more
TL;DR: TRIM63 appears to be an uncommon cause of HCM inherited in an autosomal-recessive manner and associated with concentric LVH and a high rate of LV dysfunction.
Journal ArticleDOI
The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians
Cyril Cyrus,Chittibabu Vatte,Awatif N. Al-Nafie,Shahanas Chathoth,Rudaynah A. Alali,Abdullah M. Alshehri,Mohammed Shakil Akhtar,Mohammed Almansori,Fahad Al-Muhanna,Brendan J. Keating,Amein K. Al-Ali +10 more
TL;DR: The rs5882 polymorphism (CETP) showed a significant association with CAD and therefore could be a promising marker for CAD risk estimation while the rs708272 polymorphism had a protective effect from CAD.
Journal ArticleDOI
Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT).
Amani M. Al-Amodi,Neda Z. Ghanem,Sumayh A Aldakeel,Lubna Ibrahim Al Asoom,Nazish Rafique Ahmed,Noor B. Almandil,Zaki A. Naserullah,Sana Al-Jarrash,Mohammed Shakil Akhtar,Sayed AbdulAzeez,Amein K. Al-Ali,J. Francis Borgio +11 more
TL;DR: HbA2 has a measure of unreliability in the diagnosis of β-thalassemia carriers, and can be incorrectly diagnosed as carriers.