Showing papers in "Journal of the American College of Cardiology in 2018"
TL;DR: The next generation of scientists and decision-makers will have a greater understanding of what constitutes a credible threat to public health and how to protect them from that threat.
3,748 citations
TL;DR: This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardian inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques.
1,092 citations
TL;DR: Myocarditis after ICI therapy may be more common than appreciated, occurs early after starting treatment, has a malignant course, and responds to higher steroid doses.
875 citations
TL;DR: Compared with the JNC7 guideline, the 2017 ACC/AHA guideline results in a substantial increase in the prevalence of hypertension, a small increase inThe percentage of US adults recommended for antihypertensive medication, and more intensive BP lowering for many adults taking antihyertensive medication.
736 citations
TL;DR: Strategies to improve guideline-directed use of HFrEF medications remain urgently needed, and these findings may inform targeted approaches to optimize outpatient medical therapy.
685 citations
TL;DR: This review provides an overview of air pollution and health, including assessment of exposure, impact on CV outcomes, mechanistic underpinnings, and impact ofAir pollution reduction strategies to mitigate CV risk, and concludes with future challenges.
630 citations
TL;DR: This paper reviews predictive modeling concepts relevant to cardiology such as feature selection and frequent pitfalls such as improper dichotomization, and describes the advent of deep learning and related methods collectively called unsupervised learning, which could be applied to enable precision cardiology and improve patient outcomes.
585 citations
University of Leicester1, University of Cambridge2, National Institute for Health Research3, Baker IDI Heart and Diabetes Institute4, Manchester Academic Health Science Centre5, Imperial College London6, St Bartholomew's Hospital7, Icahn School of Medicine at Mount Sinai8, Wellcome Trust Centre for Human Genetics9, Queen Mary University of London10
TL;DR: The genomic score developed and evaluated here substantially advances the concept of using genomic information to stratify individuals with different trajectories of CAD risk and highlights the potential for genomic screening in early life to complement conventional risk prediction.
522 citations
TL;DR: Evidence concerning CAC is summarized, including its pathobiology, modalities for detection, predictive role, use in prediction scoring algorithms, CAC progression, evidence that CAC changes the clinical approach to the patient and patient behavior, novel applications of CAC, future directions in scoring CAC scans, and new CAC guidelines.
516 citations
TL;DR: Tet2 deficiency in hematopoietic cells is associated with greater cardiac dysfunction in murine models of heart failure as a result of elevated IL-1β signaling, and data suggest that individuals with TET2-mediated clonal hematoiesis may be at greater risk of developing heart failure and respond better to IL- 1β-NLRP3 inflammasome inhibition.
389 citations
TL;DR: Permanent HBP was feasible and safe in a large real-world population requiring permanent pacemakers and was associated with reduction in the combined endpoint of death, HFH, or upgrade to BiVP compared to RVP in patients requiring permanentpacemakers.
Center for Drug Evaluation and Research1, Stanford University2, Icahn School of Medicine at Mount Sinai3, Cleveland Clinic4, Brigham and Women's Hospital5, San Francisco VA Medical Center6, Center for Devices and Radiological Health7, University Hospitals of Cleveland8, Harvard University9, Beth Israel Deaconess Medical Center10, Clinical Trial Service Unit11, University Health Network12, Yale University13, University of Glasgow14, Duke University15, Scripps Health16, Janssen Pharmaceutica17, Saint Louis University18
TL;DR: This publication describes uniform definitions for cardiovascular and stroke outcomes developed by the Standardized Data Collection for Cardiovascular Trials Initiative and the US Food and Drug Administration.
TL;DR: Stratifiedmedical therapy, including an IDP with linked medical therapy, is routinely feasible and improves angina in patients with no obstructive CAD, according to a randomized, controlled, blinded clinical trial.
Cardiovascular Institute of the South1, Alfred I. duPont Hospital for Children2, University of Texas Southwestern Medical Center3, Baylor College of Medicine4, Florida Atlantic University5, University of Lisbon6, University of Paris7, University of Pennsylvania8, Boston Children's Hospital9, University of Amsterdam10, Central European Institute of Technology11, Ohio State University12, Queen Mary University of London13, Vanderbilt University14, West Virginia University15, Copenhagen University Hospital16, University of São Paulo17, Erasmus University Rotterdam18, Washington University in St. Louis19, Osaka University20
TL;DR: The Expert Consensus Panel recommends that FH genetic testing become the standard of care for patients with definite or probable FH, as well as for their at-risk relatives, and more accurate risk stratification.
TL;DR: Inflammatory and immune mechanisms can link traditional and emerging risk factors to atherosclerosis, and offer novel avenues for therapeutic intervention.
TL;DR: Benefit-to-risk balance should guide treatment decisions and several medical devices are available for short-term and long-term use.
TL;DR: PFO closure in patients with high-risk PFO characteristics resulted in a lower rate of the primary endpoint as well as stroke recurrence, as evaluated by transesophageal echocardiography.
TL;DR: Pregnancy in women with heart disease continues to be associated with significant morbidity, although mortality is rare, and prediction of maternal cardiac complications in womenWith heart disease is enhanced by integration of general, lesion-specific, and delivery of care variables.
TL;DR: Current knowledge of the mechanisms and detrimental consequences of myocardial interstitial fibrosis are summarized, the potential of circulating and imaging biomarkers available to recognize different phenotypes of this lesion and track their clinical evolution are discussed, and the currently available and potential future therapies that allow its individualized management in heart failure patients are reviewed.
TL;DR: The authors focus on "healthy PA" with the emphasis on the pathophysiological effects of physical inactivity and PA on the cardiovascular system, mechanistic/triggering factors, the role of preventive actions through personal, education/environment, and societal/authoritative factors, as well as factors to provide guidance for caregivers of health promotion regarding PA.
TL;DR: The authors summarize the pathophysiology of CMD, provide an update of diagnostic testing strategies, and classify CMD into phenotypes according to severity and coexistence with atherosclerosis, representing a new frontier in cardiovascular disease reduction.
TL;DR: In this article, a randomized trial demonstrated a lower risk of cardiovascular events with SGLT-2 inhibitors in patients with type 2 diabetes (T2D) at high risk of adverse events.
TL;DR: The proposed risk factors and triggers for the syndrome are reviewed and a practical approach to diagnosis and treatment of the patients with stress cardiomyopathy is discussed, highlighting potential challenges and unresolved questions.
TL;DR: In this largest clinical trial of β-blockers for prevention of cardiotoxicity under contemporary ANT dosage, the use of carvedilol resulted in a significant reduction in troponin levels and diastolic dysfunction.
TL;DR: Observations suggest that epicardial adipose tissue is a transducer of the adverse effects of systemic inflammation and metabolic disorders on the heart, and thus, represents an important target for therapeutic interventions.
TL;DR: This trial demonstrates the technical feasibility of producing clinical-grade hESC-derived cardiovascular progenitors and supports their short- and medium-term safety, thereby setting the grounds for adequately powered efficacy studies.
TL;DR: In this article, the benefits of IVUS guidance over angiography guidance during DES implantation in all-comer patients were evaluated and the results showed that IVUS-guided drug-eluting stent implantation significantly improved clinical outcome in all comers.
TL;DR: The KB algorithm for AF detection supported by physician review can accurately differentiate sinus rhythm from AF compared with physician-interpreted 12-lead electrocardiograms (ECGs) and KB recordings.
University of California, San Diego1, Oregon Health & Science University2, Tulane Medical Center3, Columbia University4, University of Western Ontario5, University of Washington6, University of Kansas7, University of Pennsylvania8, National Institutes of Health9, University of São Paulo10, McGill University11
TL;DR: Concerted efforts to understand Lp (a) pathophysiology, together with diagnostic and therapeutic advances, are required to reduce Lp(a)-mediated risk of CVD and CAVD.
Yonsei University1, NewYork–Presbyterian Hospital2, University of Milan3, Leiden University Medical Center4, Beaumont Hospital5, University of Ottawa6, Innsbruck Medical University7, Seoul National University Hospital8, University of British Columbia9, Unica Corporation10, Chung-Ang University11, VU University Medical Center12, University of Ulsan13, Mayo Clinic14, Cedars-Sinai Medical Center15, Los Angeles Biomedical Research Institute16, Emory University17, Brigham and Women's Hospital18, Icahn School of Medicine at Mount Sinai19
TL;DR: Although ACS increases with %DS, most precursors of ACS cases and culprit lesions are nonobstructive, and plaque evaluation, including HRP, PB, and plaque composition, identifies high-risk patients above and beyond stenosis severity and aggregate plaque burden.