Mohan Viswanathan

TL;DR: Observations confirm involvement of the four exonucleases in methyl-directed mismatch repair in vivo and suggest that the low mutability of exonuclease-deficient strains is a consequence of under recovery of mutants due to a reduction in viability and/or chromosome loss associated with activation of the mismatch repair system in the absence of RecJ ex onuclease.

TL;DR: Norepinephrine-induced contraction of the caudal artery in vitro was significantly prolonged and potentiated by melatonin in a concentration-dependent manner, suggesting that these arterial binding sites are functional melatonin receptors.

TL;DR: Quantitative autoradiography was used to characterize angiotensin AT1 and AT2 receptors, in the rat aorta at three developmental ages; embryonic day 18 (E18), and postnatal weeks 2 and 8, and found thatAT2 receptors may serve an important role during stages of rapid growth of the aorte, and also have a significant function in the adult vasculature.

TL;DR: A physiological role for AT2 receptors in the process of tissue repair is suggested after 3 days after wounding when the expression of angiotensin II receptors was significantly enhanced in the dermis and in a localized band within the superficial dermis of the skin surrounding the wound.

TL;DR: The data suggest that angiotensin II AT1 receptors may have a significant role in injury-induced vascular smooth muscle proliferation and migration.