Journal ArticleDOI
Expression of angiotensin II AT2 receptors in the rat skin during experimental wound healing
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A physiological role for AT2 receptors in the process of tissue repair is suggested after 3 days after wounding when the expression of angiotensin II receptors was significantly enhanced in the dermis and in a localized band within the superficial dermis of the skin surrounding the wound.About:
This article is published in Peptides.The article was published on 1992-07-01. It has received 184 citations till now. The article focuses on the topics: Angiotensin II & Angiotensin receptor.read more
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International Union of Pharmacology. XXIII. The Angiotensin II Receptors
TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
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Physiology of local renin-angiotensin systems.
TL;DR: A large body of data is now available to support the existence of numerous organ-based RAS exerting diverse physiological effects, and universal paracrine and autocrine actions may be important in many organ systems and can mediate important physiological stimuli.
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Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
Masashi Mukoyama,Masatoshi Nakajima,Masatsugu Horiuchi,Hiroyuki Sasamura,Richard E. Pratt,Victor J. Dzau +5 more
TL;DR: In this article, a rat fetus expression library was used to clone a 363-amino acid protein with pharmacological specificity, tissue distribution, and developmental pattern of the AT2 receptor with 34% identical in sequence to the AT1 receptor, sharing a seven-transmembrane domain topology.
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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
Lutz Hein,Gregory S. Barsh,Gregory S. Barsh,Richard E. Pratt,Victor J. Dzau,Brian K. Kobilka,Brian K. Kobilka +6 more
TL;DR: Although the AT2 receptor is not required for embryonic development, it plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system.
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The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
Masatoshi Nakajima,Howard G. Hutchinson,Masahiko Fujinaga,Wataru Hayashida,Ryuichi Morishita,Lunan Zhang,Masatsugu Horiuchi,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: Results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
References
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Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing
TL;DR: It is concluded that myofibroblasts develop gradually from granulation tissue fibroblast and temporarily express a marker of smooth muscle differentiation, which may be relevant for the understanding of the mechanisms of normal and pathologic wound healing.
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Identification of angiotensin II receptor subtypes
Andrew T. Chiu,William F. Herblin,Dale E. McCall,Robert John Ardecky,David J. Carini,John V. Duncia,Lori J. Pease,Pancras C. Wong,Ruth R. Wexler,Alexander L. Johnson,Pieter B.M.W.M. Timmermans +10 more
TL;DR: Two distinct subtypes of the angiotensin II receptor in the rat adrenal gland are demonstrated using radioligand binding and tissue section autoradiography and the discovery of two structurally dissimilar, nonpeptide compounds that show reciprocal selectivity for the two subtypes.
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Preliminary biochemical characterization of two angiotensin II receptor subtypes.
TL;DR: There is a good correlation between the affinities of the selected agonists and antagonists for the two subtypes in the various tissues tested which is a usual requirement for receptor classification.
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Expression of AT2 receptors in the developing rat fetus.
TL;DR: The transient expression of AT2 receptors in the mesenchyme of the fetus suggests a role of angiotensin II in fetal development.
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Angiotensin and cell growth: a link to cardiovascular hypertrophy?
TL;DR: The possible role of angiotensin II as a growth factor or growth modulator, and its relationship to the development of cardiovascular hypertrophy as an initiating event of the vicious circle in organ damage, is an area of intensive research at the present time.